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Table 1 Genome-wide search for early AMD association

From: Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

Rs identifier chr:pos [hg19] EA OA EAF logOR SE OR P N cases N controls Known advanced AMD locus (Fritsche et al.) Locus name
Novel early AMD loci:
 rs4844620 1:207980901 g a 0.79 0.095 0.017 1.10 4.7E-08 14,031 91,179 no CD46
 rs547154 6:31910938 g t 0.91 0.218 0.025 1.24 1.3E-18 14,027 91,137 yes C2
 rs943080 6:43826627 t c 0.51 0.080 0.015 1.08 4.7E-08 13,220 85,747 yes VEGFA
 rs13278062 8:23082971 t g 0.52 0.080 0.014 1.08 2.0E-08 13,644 85,908 yes TNFRSF10A
 rs5817082 16:56997349 c ca 0.26 0.108 0.017 1.11 1.0E-10 12,599 81,863 yes CETP
 rs11569415 19:6716279 a g 0.21 0.116 0.018 1.12 1.7E-10 13,115 83,117 yes C3
Known early AMD loci:
 rs4658046 1:196670757 c t 0.39 0.321 0.014 1.38 2.9E-114 14,034 91,201 yes CFH
 rs3750847 10:124215421 t c 0.22 0.384 0.017 1.47 1.3E-116 14,025 91,171 yes ARMS2/HTRA1
  1. EA effect allele, OA other allele, EAF effect allele frequency, logOR log odds ratio, SE standard error of logOR; OR odds ratio, P double GC corrected early association P value from the meta-analysis
  2. The table shows the eight genome-wide significant (P < 5.0 × 10− 8) lead variants from the early AMD meta-analysis. The second last column indicates whether the locus was identified by Fritsche et al. for advanced AMD [9]