Rs identifier | chr:pos [hg19] | Locus (Holliday et al.) | EA | OA | Holliday et al. | this meta-analysis (excluding ARIC, CHS) | P (combined) | Known advanced AMD locus (Fritsche et al.) | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EAF | OR [CI 95%] | P | EAF | OR [CI 95%] | P | Neff | |||||||
Experiment-wise significant association (P < 0.05/14) | |||||||||||||
 rs1967689 | 1:208039471 | CD34,CD46 | C | G | 0.25 | 0.85 [0.80;0.91] | 5.1E-06 | 0.24 | 0.93 [0.90;0.96] | 2.5E-05 | 42,119 | 5.5E-09 | no |
 rs621313 | 11:88913663 | TYR | A | G | 0.51 | 0.87 [0.83;0.92] | 3.5E-06 | 0.52 | 0.95 [0.93;0.98] | 6.8E-04 | 41,661 | 1.7E-07 | no |
 rs6857 | 19:45392254 | PVRL2 | T | C | 0.15 | 0.81 [0.74;0.88] | 1.4E-06 | 0.16 | 0.92 [0.89;0.96] | 7.1E-05 | 38,938 | 9.8E-09 | yes |
 rs2075650 | 19:45395619 | APOE/TOMM40 | A | G | 0.86 | 1.23 [1.13;1.34] | 1.1E-06 | 0.86 | 1.08 [1.04;1.13] | 2.6E-04 | 40,405 | 9.0E-08 | yes |
No experiment-wise significant association (P ≥ 0.05/14): | |||||||||||||
 rs16851585 | 1:177568799 | – | C | G | 0.92 | 0.77 [0.69;0.86] | 5.0E-06 | 0.89 | 1.04 [0.99;1.09] | 0.099 | 42,119 | 0.74 | no |
 rs6721654 | 2:121301911 | GLI2,INHBB | T | C | 0.08 | 1.26 [1.14;1.4] | 6.5E-06 | 0.08 | 1.01 [0.96;1.07] | 0.65 | 41,718 | 0.017 | no |
 rs17586843 | 4:116924184 | – | T | C | 0.78 | 1.18 [1.1;1.27] | 1.5E-06 | 0.78 | 1.02 [0.98;1.05] | 0.31 | 42,119 | 0.0048 | no |
 rs7750345 | 6:106260128 | – | A | G | 0.75 | 1.16 [1.09;1.24] | 6.8E-06 | 0.74 | 1.02 [0.98;1.05] | 0.32 | 42,119 | 0.0049 | no |
 rs2049622 | 7:42176282 | GLI3 | A | G | 0.49 | 0.87 [0.83;0.93] | 8.9E-06 | 0.52 | 0.99 [0.96;1.02] | 0.41 | 42,060 | 0.015 | no |
 rs11986011 | 8:127332657 | FAM84B | T | C | 0.02 | 2.5 [1.68;3.71] | 5.0E-06 | – | – | – | – |  | no |
 rs6480975 | 10:54574996 | MBL2 | C | G | 0.84 | 1.21 [1.12;1.32] | 2.8E-06 | 0.85 | 0.99 [0.95;1.03] | 0.63 | 40,651 | 0.17 | no |
 rs4293143 | 11:82821382 | PCF11,RAB30 | T | G | 0.69 | 0.85 [0.79;0.91] | 7.8E-06 | 0.70 | 0.99 [0.96;1.02] | 0.50 | 42,119 | 0.0094 | no |
 rs9646096 | 13:38065446 | POSTN,TRPC4 | A | C | 0.95 | 0.74 [0.65;0.84] | 6.0E-06 | 0.96 | 0.99 [0.92;1.06] | 0.76 | 39,782 | 0.0087 | no |
 rs10406174 | 19:3944240 | ITGB1BP3,DAPK3 | A | G | 0.11 | 1.24 [1.13;1.36] | 5.6E-06 | 0.11 | 1.00 [0.93;1.07] | 0.92 | 17,936 | 0.0057 | yes |