Skip to main content

Table 2 Clusters of shared significantly altered GO biological processes, determined by REVIGO (see Table S6)

From: Comparative transcriptome analysis of Parkinson’s disease and Hutchinson-Gilford progeria syndrome reveals shared susceptible cellular network processes

Cluster representative Direction of regulation Keywords Prior literature findings
regulation of intracellular calcium activated chloride channel activity down in PD, up in HGPS movement of adaptive immune cells adaptive immunity reduced during aging [68]
regulation of peptidyl-threonine phosphorylation down in PD, majority of genes down in HGPS (a few up) DNA replication, telomere capping genomic instability is a hallmark of aging [68] involved in premature aging and neurodegenerative diseases [12]
interleukin-8-mediated signaling pathway cytokine pathways: down in PD, up in HGPS; adiponectin pathway: down in both PD and HGPS cytokine signaling, adiponectin pathway cytokine secretion in senescent cells during aging [68]
negative regulation of eosinophil activation down in PD, up in HGPS GPCR signaling, neuropeptide signaling GPCRs in aging and PD [69]; GPCRs in (premature) cellular senescence [70]; neuropeptide in brain - neuromodulators [71]; neuropeptides in skin - wound healing [72]
response to axon injury down in PD, majority of genes down in HGPS (a few up) response to ROS Increased levels of ROS related to aging [13, 68]
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure down in PD, up in HGPS blood pressure, metanephros (kidney) None. GO terms only show up because of overlap with brain and skin processes.
regulation of cell projection assembly down in PD, majority of genes down in HGPS (a few up) cell projection organization genes from cell projection GO terms as modifiers of neurodegeneration in PD [73]; cell projection in GO analysis of progerin-associated proteins [74]
viral genome replication down in PD, majority of genes down in HGPS (a few up) viral processes Viral immunity decreases during aging [75]
myoblast development down in PD, majority of genes down in HGPS (a few up) nervous system development PD might be associated with neurodevelopment [76]
morphogenesis of an endothelium down in PD, majority of genes down in HGPS (a few up) endothelial morphogenesis application in neural stem cell-based therapy for PD [77]
circadian rhythm down in PD, majority of genes down in HGPS (a few up) circadian rhythm Decrease of circadian rhythm associated with neurodegenerative disorders [78] and premature aging [79]
dopamine biosynthetic process down in PD, up in HGPS dopamine dopamine in diagnosis and treatment of PD [80]; dopamine-specific processes in progerin-induced aging [13]
regulation of cytokinesis down in PD, majority of genes up in HGPS (a few down) cytokinesis decrease of the number of cell divisions related to aging [81]
response to electrical stimulus down in PD, majority of genes up in HGPS (a few down) electrical stimulus effect of electrical stimulation on gait in PD patients [82]
calcium-mediated signaling using intracellular calcium source majority of genes down in PD and HGPS calcium signaling role in cellular senescence [83]; candidate hallmark of aging [68]; calcium signaling in premature aging [12]