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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Unraveling the molecular heterogeneity in type 2 diabetes: a potential subtype discovery followed by metabolic modeling

Fig. 2

Workflow for cluster-based metabolic modeling. HMR2 model was used as the generic model. The personalized metabolic models were reconstructed by integrating gene expression data into the HMR2 using the E-Flux algorithm. Diabetic models were categorized into three groups based on the clusters obtained from the hierarchical clustering of T2DM patients. FVA was employed to obtain maximum and minimum possible fluxes in each reaction. Perturbed reactions in each cluster in comparison to the healthy group were identified by applying t-test on obtained fluxes

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