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Table 1 The results of 31 childhood-onset asthma-relevant risk genes based on current integrative genomics analysis

From: Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma

Gene name Risk eSNPs LBF Sherlock-based P-value (Dataset #3) FDR value (Dataset #3) MAGMA-based P-value
(Dataset #1)
MAGMA-based corrected P-value
(Dataset #1)
Sherlock-based P-value (Dataset #4) GWAS Catalog
HLA-DQA1 rs17426593, rs1150753, rs660895 12.91 7.87 × 10− 7 2.05 × 10− 4 1.76 × 10− 68 3.38 × 10− 64 3.79 × 10− 4 Reported genes
PSMB9 rs2071534, rs4148882 12.17 7.87 × 10− 7 2.05 × 10− 4 1.08 × 10− 9 2.09 × 10− 5 2.43 × 10− 4 Novel genes
HLA-DRB5 rs9272346, rs2071295 11.52 7.87 × 10− 7 2.05 × 10− 4 9.80 × 10−17 1.88 × 10− 12 3.19 × 10− 5 Reported genes
HLA-DPB1 rs429916, rs2855430 11.26 7.87 × 10− 7 2.05 × 10− 4 5.12 × 10− 11 9.85 × 10− 7 1.52 × 10− 6 Novel genes
HLA-DRB1 rs9272346, rs660895 10.91 7.87 × 10− 7 2.05 × 10− 4 1.47 × 10− 24 2.83 × 10− 20 7.59 × 10− 6 Reported genes
TAP2 rs4148882, rs241456 8.70 7.87 × 10−7 2.05 × 10− 4 1.07 × 10− 33 2.06 × 10− 29 1.52 × 10− 6 Novel genes
TLR6 rs5743592, rs5743595 7.38 7.87 × 10−7 2.05 × 10− 4 1.83 × 10− 26 3.51 × 10− 22 1.52 × 10− 6 Reported genes
PMM1 rs203319, rs132774 7.36 7.87 × 10−7 2.05 × 10− 4 5.24 × 10−9 1.01 × 10− 4 1.52 × 10− 6 Novel genes
MPHOSPH9 rs7299943, rs1716160 7.20 7.87 × 10−7 2.05 × 10− 4 3.51 × 10−9 6.75 × 10− 5 1.67 × 10− 5 Reported genes
PSMD3 rs12311409, rs8077456 6.83 1.57 × 10− 6 2.05 × 10−4 6.49 × 10− 42 1.25 × 10− 37 3.27 × 10−2 Novel genes
HLA-DOB rs2071474, rs2621332 6.67 1.57 × 10− 6 2.05 × 10−4 6.25 × 10− 32 1.20 × 10−27 1.52 × 10− 6 Novel genes
ME2 rs1810129, rs584357 6.60 1.57 × 10−6 2.05 × 10−4 1.26 × 10−9 2.42 × 10− 5 1.88 × 10− 4 Novel genes
ACTR1A rs2281879, rs10883723 6.55 1.57 × 10−6 2.05 × 10−4 3.42 × 10−9 6.58 × 10−5 3.03 × 10− 6 Novel genes
DEXI rs12935657, rs741175 6.42 1.57 × 10−6 2.05 × 10−4 2.32 × 10−13 4.45 × 10−9 1.52 × 10− 6 Novel genes
NSMCE1 rs3024530, rs6498001 6.22 1.57 × 10−6 2.05 × 10−4 6.37 × 10−12 1.22 × 10−7 6.37 × 10−5 Novel genes
JAZF1 rs2189966, rs1635852 6.18 1.57 × 10−6 2.05 × 10−4 2.67 × 10−9 5.13 × 10−5 5.61 × 10− 5 Reported genes
TDRKH rs868867, rs1054475 6.18 1.57 × 10−6 2.05 × 10−4 5.17 × 10− 11 9.95 × 10−7 3.03 × 10− 6 Reported genes
SMARCE1 rs1358174, rs757411 6.06 1.57 × 10−6 2.05 × 10−4 4.18 × 10− 10 8.05 × 10− 6 7.59 × 10− 6 Reported genes
AHI1 rs2757649, rs11154801 5.89 1.57 × 10−6 2.05 × 10−4 2.10 × 10−6 4.03 × 10−2 1.84 × 10− 4 Novel genes
SLC15A2 rs9826473, rs1806656 5.77 1.57 × 10−6 2.05 × 10−4 3.32 × 10−9 6.39 × 10−5 3.03 × 10− 6 Novel genes
RAD50 rs2069812 5.60 1.57 × 10−6 2.05 × 10−4 8.32 × 10−25 1.60 × 10− 20 6.22 × 10−5 Reported genes
HLA-B rs3130564, rs3130564 5.50 1.57 × 10−6 2.05 × 10−4 5.61 × 10−29 1.08 × 10−24 2.88 × 10− 4 Reported genes
LST1 rs2071593, rs2855812, rs1861856 5.14 6.30 × 10−6 7.39 × 10−4 1.31 × 10−15 2.52 × 10−11 1.52 × 10− 6 Novel genes
POLI rs2276182, rs3730783 5.12 6.30 × 10−6 7.39 × 10−4 9.06 × 10−12 1.74 × 10−7 1.52 × 10− 6 Reported genes
HSPA1A rs2276133, rs4143780 4.80 7.87 × 10−6 8.10 × 10−4 4.66 × 10−13 8.97 × 10−9 3.75 × 10−2 Novel genes
SLC22A5 rs17622656, rs11950562 4.54 1.42 × 10−5 1.33 × 10−3 1.77 × 10−7 3.41 × 10−3 3.03 × 10−6 Reported genes
CTSW rs659824, rs494003 4.15 2.52 × 10−5 2.06 × 10−3 1.08 × 10−7 2.08 × 10−4 3.94 × 10− 5 Novel genes
NDFIP1 rs6498142, rs449454 3.93 4.25 × 10−5 2.99 × 10−3 4.41 × 10−13 8.49 × 10−9 3.03 × 10−6 Reported genes
HLA-C rs1063646, rs3130564 3.71 5.83 × 10−5 3.73 × 10−3 1.32 × 10−15 2.54 × 10−11 1.52 × 10− 5 Novel genes
CD52 rs6703878, rs1071849, rs3780032 1.42 7.75 × 10−4 2.19 × 10−2 2.04 × 10−6 3.93 × 10− 2 9.21 × 10− 4 Novel genes
ARL3 rs10786679, rs2160203 0.55 1.91 × 10−3 4.48 × 10−2 3.07 × 10−8 5.90 × 10−4 2.58 × 10− 4 Novel genes