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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Genomic amplification of chromosome 20q13.33 is the early biomarker for the development of sporadic colorectal carcinoma

Fig. 1

Profiles of chromosomal aberrations in sporadic CRC. a Overall frequency of chromosomal copy number aberrations detected by a high resolution aCGH (Agilent 1x1M oligonucleotide probes) in sporadic CRCs (n = 5). All gain or loss events were identified using log2 ratios of fluorescent signals between labeled tumor and adjacent non-tumor parts of CRCs. b Scatter plots were used to show quantitative real-time PCR analyses of CDH4 gene loci for 377 sporadic paired CRC tissues. The CRC tumor parts were denoted by black triangles, whereas the non-tumor ones were denoted by unfilled circles. Both parts were compared to detect whether copy number alterations of CRC tumors could be correlated with the genomic alterations of the adjacent CRC non-tumors (correlation coefficient R2 < 0.01). * P < 0.05, ** P < 0.01, and *** P < 0.001

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