Fig. 2

22 significantly mutated protein domains and their mutational spectra. (a) 11 reported protein domains were also identified by Yang et al. [28] for other cancers. Here, “others” represent those protein domains that were only reported in [28]. (b) and (c) The distributions of mutations in the 22 protein domains in terms of survival status and staging. Left panel: The percentage of surviving (and deceased) patients (resp. patients in a stage) in which each protein domain is mutated. Right panel: The distribution of the four types of mutations in the groups of patients for the 22 protein domains. Middle column: The number of patients in which a protein domain is mutated. Of note, none of these protein domains was mutated in the patients listed at the end of each group. SNP, single nucleotide polymorphism; DEL, deletion; INS, insertions; DNP, double nucleotide polymorphism. (d) The Kaplan-Meier survival analysis for protein domains fn3 and I-set