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Table 4 Top genes for classification of tumors based on ER status. Genes represent those that were present in at least 10% of the top 100 pairs in at least one of the feature selection methods. Feature selection columns denote the number of occurrences in the top 100 gene pairs

From: Considerations for feature selection using gene pairs and applications in large-scale dataset integration, novel oncogene discovery, and interpretable cancer screening

Gene Symbol Gene Name TSP AM AA FM FA Function Location
ATP6AP2 ATPase H+ transporting accessory protein 2 0 39 3 1 0 Vacuolar-ATPase, pH control Xp11.4
CSNK1A1 Casein kinase 1 alpha 1 0 13 3 0 0 Tumor suppressor, Wnt/β-catenin signaling 5q32
ESR1 Estrogen receptor 1 100 0 45 0 99 Estrogen signaling 6q25.1–2
INAVA Innate immunity activator 1 1 17 0 1 Adherens junctions 1q32.1
SOX11 SRY-box 11 0 0 12 0 2 Transcription factor, cell fate 2p25.2
TPM3 Tropomyosin 3 0 11 2 0 0 Stabilization of actin filaments 1q21.3
U2AF1 U2 small nuclear RNA auxiliary factor 1 1 34 22 93 1 Splicing 21q22.3