Table 5 Top genes for classification of tumors based on HER2 status. Genes represent those that were present in at least 10% of the top 100 pairs in at least one of the feature selection methods. Feature selection columns denote the number of occurrences in the top 100 gene pairs
Gene Symbol | Gene Name | TSP | AM | AA | FM | FA | Function | Location |
|---|---|---|---|---|---|---|---|---|
GRB7 | Growth factor receptor bound protein 7 | 100 | 0 | 20 | 0 | 100 | HER2 signaling pathway | 17q12 |
PNMT | Phenolethanolamine N-methyltransferase | 0 | 0 | 42 | 0 | 0 | Catecholamine biosynthesis | 17q12 |
TCAP | Titin-cap | 0 | 4 | 31 | 16 | 0 | Scaffolding protein | 17q12 |
TPM3 | Tropomyosin 3 | 0 | 12 | 3 | 1 | 0 | Stabilization of actin filaments | 1q21.3 |
U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 0 | 80 | 1 | 57 | 0 | Splicing | 21q22.3 |