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Table 5 Top genes for classification of tumors based on HER2 status. Genes represent those that were present in at least 10% of the top 100 pairs in at least one of the feature selection methods. Feature selection columns denote the number of occurrences in the top 100 gene pairs

From: Considerations for feature selection using gene pairs and applications in large-scale dataset integration, novel oncogene discovery, and interpretable cancer screening

Gene Symbol Gene Name TSP AM AA FM FA Function Location
GRB7 Growth factor receptor bound protein 7 100 0 20 0 100 HER2 signaling pathway 17q12
PNMT Phenolethanolamine N-methyltransferase 0 0 42 0 0 Catecholamine biosynthesis 17q12
TCAP Titin-cap 0 4 31 16 0 Scaffolding protein 17q12
TPM3 Tropomyosin 3 0 12 3 1 0 Stabilization of actin filaments 1q21.3
U2AF1 U2 small nuclear RNA auxiliary factor 1 0 80 1 57 0 Splicing 21q22.3