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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Pan-cancer analysis of differential DNA methylation patterns

Fig. 3

Comparison of model performance. (a-i) The number of true positives among the top-ranked CpG sites by each of the three DM calling methods. “P” refers to PanDM; “E” refers to “Empirical Null”, corresponding to the strategy of fitting two-normal mixtures to the single-study-based p-values of each cancer type individually; “S” indicates our separate analyses based on the rank of the p-values. The two separate analyses produce almost the same results when detecting top-ranked CpG sites. PanDM identifies more true positive DM CpG sites

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