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Table 1 Training and test set composition. a The OOI Malignant set includes subjects out of indication due only to having a positive lung cancer diagnosis from bronchoscopy. b The OOI Other set includes subjects that are out of indication due to other reasons (never smokers, concurrent or prior cancer or metastatic to lung)

From: Improving lung cancer risk stratification leveraging whole transcriptome RNA sequencing and machine learning across multiple cohorts

  Set Cohort Pre-Test Risk Group N
Low Intermediate High Missing
Training (N = 1502) Primary (Within Indication) AEGIS 25 50 78 36 189
Registry 7 80 35 . 122
Total      311
OOI Malignanta AEGIS 1 24 477 77 579
Total      579
OOI Otherb AEGIS 48 122 217 82 469
Registry 22 85 33 3 143
Total      612
Test (N = 412) Primary (Within Indication) AEGIS 58 82 106 . 246
Registry 22 106 38 . 166
Total      412