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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers

Fig. 4

Effects of cold acclimation and exercise training on gene expression at the pathway level. a Top 10 positively enriched (upregulated) gene sets in human skeletal muscle in response to cold acclimation (red bars), and exercise training (blue bars) according to gene set enrichment analysis. b Top 10 negatively enriched (upregulated) gene sets in human skeletal muscle in response to cold acclimation (red bars), and exercise training (blue bars) according to gene set enrichment analysis. c Correlation plot of Normalized Enrichment Scores (NES) derived from GSEA for the comparison pre-cold vs post-cold (y-axis) and the comparison pre-exercise vs post-exercise (x-axis). Gene sets with NES values above 2 in both interventions are indicated in red. d Venn diagram of significantly upregulated gene sets (q < 0.05) in human skeletal muscle in response to exercise training and cold acclimation. e Gene sets meeting statistical significance q < 0.0001 for the comparison pre-cold vs post-cold (red) and the comparison pre-exercise vs post-exercise (blue). f Heatmap showing individual gene expression changes of the 25 most highly induced genes by cold that are part of the gene set KEGG_ECM.RECEPTOR.INTERACTIONS. Red indicates upregulated, blue indicates downregulated

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