Fig. 4From: Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteersEffects of cold acclimation and exercise training on gene expression at the pathway level. a Top 10 positively enriched (upregulated) gene sets in human skeletal muscle in response to cold acclimation (red bars), and exercise training (blue bars) according to gene set enrichment analysis. b Top 10 negatively enriched (upregulated) gene sets in human skeletal muscle in response to cold acclimation (red bars), and exercise training (blue bars) according to gene set enrichment analysis. c Correlation plot of Normalized Enrichment Scores (NES) derived from GSEA for the comparison pre-cold vs post-cold (y-axis) and the comparison pre-exercise vs post-exercise (x-axis). Gene sets with NES values above 2 in both interventions are indicated in red. d Venn diagram of significantly upregulated gene sets (q < 0.05) in human skeletal muscle in response to exercise training and cold acclimation. e Gene sets meeting statistical significance q < 0.0001 for the comparison pre-cold vs post-cold (red) and the comparison pre-exercise vs post-exercise (blue). f Heatmap showing individual gene expression changes of the 25 most highly induced genes by cold that are part of the gene set KEGG_ECM.RECEPTOR.INTERACTIONS. Red indicates upregulated, blue indicates downregulatedBack to article page