BMC Medical Genomics

Table 3 Associations between CpG sites and target organ damage in GENOA African Americans

From: Epigenetic loci for blood pressure are associated with hypertensive target organ damage in older African Americans from the genetic epidemiology network of Arteriopathy (GENOA) study

CpG site	Gene	N	Unadjusted		BMI adjusted		Smoking adjusted		Diabetes adjusted		All adjusted
CpG site	Gene	N	Beta	FDR q	Beta	FDR q	Beta	FDR q	Beta	FDR q	Beta	FDR q
*Estimated glomerular filtration rate*
cg06690548	SLC7A11	1211	3.717	0.004	3.564	0.004	3.722	0.004	3.703	0.004	3.571	0.004
cg10601624	–	1211	−5.578	0.005	−5.661	0.004	−5.539	0.005	−5.625	0.004	−5.646	0.004
*Urine albumin-to-creatinine ratio*
cg16246545	PHGDH	1213	−0.306	0.066	−0.279	0.106	−0.307	0.066	−0.194	0.356	−0.18	0.438
cg14476101	PHGDH	1213	−0.304	0.006	−0.274	0.017	−0.304	0.006	−0.213	0.074	−0.198	0.112
cg19693031	TXNIP	1213	−0.433	1.3E-07	−0.415	4.6E-07	−0.433	1.3E-07	−0.211	0.024	−0.212	0.032
cg06690548	SLC7A11	1213	−0.305	0.001	−0.296	0.001	−0.305	0.001	−0.264	0.009	−0.258	0.012
cg00574958	CPT1A	1213	−0.439	5.9E-06	−0.387	1.1E-04	−0.440	5.8E-06	−0.241	0.024	−0.218	0.054
cg22304262	SLC1A5	1213	−0.233	0.087	−0.222	0.108	−0.238	0.084	−0.146	0.383	−0.132	0.491
*Left ventricular mass / height^2.7*
cg19693031	TXNIP	1170	−1.345	0.058	−0.743	0.601	−1.347	0.057	−0.342	0.883	−0.161	0.901
cg00574958	CPT1A	1170	−1.835	0.031	−0.663	0.601	−1.843	0.030	−1.116	0.678	−0.282	0.901

N: sample size, Beta: beta coefficient, SE: standard error, CpG: cytosine-phosphate-guanine, smoking: current smoking status
Gene names are from UCSC Genome Browser
All models were adjusted for age, sex, white blood cell counts, time difference between phase 1 and 2, and 10 genetic principal components
Urine albumin-to-creatinine ratio was log transformed
Only results with FDR q < 0.1 are shown in Table 3
FDR q-value was bolded if < 0.1

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