Fig. 2From: Whole-exome sequencing reveals potential mechanisms of drug resistance to FGFR3-TACC3 targeted therapy and subsequent drug selection: towards a personalized medicineNetwork of mutated genes pre- and post-pazopanib resistance. Green nodes denote genes that were mutated both before and after resistance; yellow nodes denote genes that were mutated before resistance but not afterwards; blue nodes denote genes that were newly mutated after resistance. Node shape codes for the number of distinct mutations a gene had: circle = 1, square = 2, diamond = 4. Node size corresponds to the number of interaction partners a gene had in the PPI network. Two genes were connected by an edge if their corresponding (canonical) protein products physically interacted in the PPI networkBack to article page