Fig. 1

A flowchart of current study strategy to analyze the MRs of CC. a 10 gene expression datasets of cervical cancer tissues and normal cervical tissues were selected from GEO database. b VIPER was used to convert a DE profile of genes to a DA profile of MRs. Top activated or suppressed MRs were selected from 5 discovery datasets. c The top MRs were validated in the other 5 validation datasets. d the DE profiles of the top MRs in the 5 discovery datasets were extracted. DA-DE consistent MRs were selected. e Synergistic MR pairs were identified by comparing the distribution of ECA for common and unique regulons of two MRs. f The top significant synergistic MR pair and their regulons were visualized in a network. g The common regulons of the two MRs were functionally annotated using DAVID. h The clinical significance the two MRs was further analyzed using additional data such as TCGA