Fig. 6

Tumor samples with high or low expression of CENPF and TOP2A are associated with gene somatic mutations. a Network view of CENPF, TOP2A and genes with somatic mutations in TCGA samples with CC. Wilcoxon Rank-Sum test P < 0.1 was used to select associations between a type of mutation and gene expression of a MR. Loss of function (LOF) mutations include nonsense, splice site mutations and frameshift mutations. b Examples of mutations in three genes (TP53, MSH2 and RB1) associated with expression level of CENPF or TOP2A. (two tailed Wilcoxon Rank-Sum test, * P < 0.1, ** P < 0.05) c Expression of CENPF or TOP2A in 67 samples with missense mutations in any of the 28 genes compared to 124 samples with none of these mutations. d DAVID function annotation of the genes with mutations associated with high expression of CENPF or TOP2A