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Fig. 7 | BMC Medical Genomics

Fig. 7

From: TOP2A and CENPF are synergistic master regulators activated in cervical cancer

Fig. 7

Expression of CENPF and TOP2A in CC compared to other cancer types. a Expression of TOP2A and CENPF in 33 cancer types (red) and matched normal tissues (green). Data were from TCGA and GTEx analyzed using GEPIA2. Comparisons with ANOVA P < 1E-10 and fold change> 4 were highlighted in red text and marked with a *. Red and green horizontal dotted lines reflect the median value of expression for CESC and normal cervical tissue respectively. Abbreviations for cancer types are: ACC, Adrenocortical carcinoma; BLCA, Bladder Urothelial Carcinoma; BRCA, Breast invasive carcinoma; CESC, Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, Cholangio carcinoma; COAD, Colon adenocarcinoma; DLBC, Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; ESCA, Esophageal carcinoma; GBM, Glioblastoma multiforme; HNSC, Head and Neck squamous cell carcinoma; KICH, Kidney Chromophobe; KIRC, Kidney renal clear cell carcinoma; KIRP, Kidney renal papillary cell carcinoma; LAML, Acute Myeloid Leukemia; LGG, Brain Lower Grade Glioma; LIHC, Liver hepatocellular carcinoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma; MESO, Mesothelioma; OV, Ovarian serous cystadenocarcinoma; PAAD, Pancreatic adenocarcinoma; PCPG, Pheochromocytoma and Paraganglioma; PRAD, Prostate adenocarcinoma; READ, Rectum adenocarcinoma; SARC, Sarcoma; SKCM, Skin Cutaneous Melanoma; STAD, Stomach adenocarcinoma; TGCT, Testicular Germ Cell Tumors; THCA, Thyroid carcinoma; THYM, Thymoma; UCEC, Uterine Corpus Endometrial Carcinoma; UCS, Uterine Carcinosarcoma; UVM, Uveal Melanoma; b Expression analysis of TOP2A and CENPF using Bittner Multi-cancer Dataset analyzed by Oncomine. The expression in cervical cancer (CC, group 4) was compared to all other cancer types using Student’s t-test. P-values are indicated. The blue horizontal dotted lines reflect the median value of the expression in CC

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