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Table 2 Patient characteristics in different molecular subgroups

From: Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

  With any mutation No mutation P value With APC mutation With other mutation but no APC mutation P value With TP53 mutation With other mutation but no TP53 mutation P value With RAS mutation With other mutation but no RAS mutation P value
Patients - no. 142 87   41 101   66 76   79 63  
Age
 Median (range) - yr 66 (40–90) 65 (31–87)   64 (42–90) 67 (40–82)   65 (44–82) 67 (40–90)   65 (42–88) 67 (40–90)  
 Mean - yr 66.3 65.2   66.0 66.4   65 67.4   65.8 67.0  
  < 50 - no. 11 9 0.508 5 6 0.845 5 6 0.185 5 6 0.517
 50–70 - no. 77 47   21 56   40 37   46 31  
  > 70 - no. 54 31   15 39   21 33   28 26  
Gender - no.    0.204    0.852    0.002    0.096
 Male 85 60   24 61   49 36   43 42  
 Female 57 27   17 40   17 40   36 21  
Clinical stage - no.    0.041    0.631    0.204    0.019
 I 35 18   12 23   21 14   24 11  
 II 37 32   12 25   18 19   13 24  
 III 49 33   11 38   18 31   31 18  
 IV 21 4   6 15   9 12   11 10  
Location sampled - no.    0.062    0.266    0.213    0.136
 Rectum 117 60   35 82   57 60   70 47  
 Left Colon 8 11   1 7   2 6   2 6  
 Right Colon 9 12   1 8   2 7   3 6  
 Rectosigmoid Junction 8 4   4 4   5 3   4 4  
Differentiation - no.    0.892    0.128    0.156    0.400
 Well 8 5   0 8   5 3   6 2  
 Moderate 113 67   36 77   50 63   60 53  
 Poor 16 12   3 13   11 5   10 6  
 Unknowna 5 3   2 3   0 5   3 2  
Metastasis- no.    0.017    1.000    0.815    0.814
 With Metastasis 21 4   6 15   9 12   11 10  
 Without Metastasis 121 83   35 86   57 64   68 53  
Treatment after surgery - no.    0.405    0.133    0.611    1.000
 With adjuvant therapy 77 52   26 51   34 43   42 35  
 Without adjuvant therapy 63 33   14 49   31 32   35 28  
 N/A 2 2   1 1   1 1   2 0  
Tumor size - cm    0.332    0.066    0.598    0.479
 Median (range) 4 (1.5–13) 4 (1.5–10)   4 (1.5–12) 4.3 (1.5–13)   4 (1.5–11) 4 (1.5–13)   4 (1.5–13) 4 (1.5–8.5)  
 Mean 4.4 4.2   4.0 4.6   4.3 4.5   4.6 4.3  
CEA - ng/mL    0.057    0.703    0.491    1.000
 0.0–5.0 87 63   26 61   39 48   49 38  
  > 5.0 53 21   14 39   27 26   30 23  
 N/A 2 3   1 1   0 2   0 2  
  1. P values were calculated with the use of χ2 test or Fisher exact test for categorical variables and Kruskal-Wallis test for continuous variables
  2. a Reported as mucinous adenocarcinomas
  3. N/A not available