Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

Xu, Chang; Peng, Danli; Li, Jialu; Chen, Meihua; Hu, Yujie; Hou, Mingliang; Shang, Qingjuan; Liang, Qi; Li, Jie; Li, Wenfeng; Wu, Xiaoli; Liu, Changbao; Hu, Wanle; Cai, Mao; Zhang, Huxiang; Chen, Guorong; Yu, Lingling; Zheng, Xiaoqun; Jiang, Feizhao; Luan, Ju; Jin, Shengnan; Ding, Chunming

doi:10.1186/s12920-020-00804-y

Table 2 Patient characteristics in different molecular subgroups

From: Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

	With any mutation	No mutation	P value	With *APC* mutation	With other mutation but no *APC* mutation	P value	With *TP53* mutation	With other mutation but no *TP53* mutation	P value	With *RAS* mutation	With other mutation but no *RAS* mutation	P value
Patients - no.	142	87		41	101		66	76		79	63
Age
Median (range) - yr	66 (40–90)	65 (31–87)		64 (42–90)	67 (40–82)		65 (44–82)	67 (40–90)		65 (42–88)	67 (40–90)
Mean - yr	66.3	65.2		66.0	66.4		65	67.4		65.8	67.0
< 50 - no.	11	9	0.508	5	6	0.845	5	6	0.185	5	6	0.517
50–70 - no.	77	47		21	56		40	37		46	31
> 70 - no.	54	31		15	39		21	33		28	26
Gender - no.			0.204			0.852			0.002			0.096
Male	85	60		24	61		49	36		43	42
Female	57	27		17	40		17	40		36	21
Clinical stage - no.			0.041			0.631			0.204			0.019
I	35	18		12	23		21	14		24	11
II	37	32		12	25		18	19		13	24
III	49	33		11	38		18	31		31	18
IV	21	4		6	15		9	12		11	10
Location sampled - no.			0.062			0.266			0.213			0.136
Rectum	117	60		35	82		57	60		70	47
Left Colon	8	11		1	7		2	6		2	6
Right Colon	9	12		1	8		2	7		3	6
Rectosigmoid Junction	8	4		4	4		5	3		4	4
Differentiation - no.			0.892			0.128			0.156			0.400
Well	8	5		0	8		5	3		6	2
Moderate	113	67		36	77		50	63		60	53
Poor	16	12		3	13		11	5		10	6
Unknown^a	5	3		2	3		0	5		3	2
Metastasis- no.			0.017			1.000			0.815			0.814
With Metastasis	21	4		6	15		9	12		11	10
Without Metastasis	121	83		35	86		57	64		68	53
Treatment after surgery - no.			0.405			0.133			0.611			1.000
With adjuvant therapy	77	52		26	51		34	43		42	35
Without adjuvant therapy	63	33		14	49		31	32		35	28
N/A	2	2		1	1		1	1		2	0
Tumor size - cm			0.332			0.066			0.598			0.479
Median (range)	4 (1.5–13)	4 (1.5–10)		4 (1.5–12)	4.3 (1.5–13)		4 (1.5–11)	4 (1.5–13)		4 (1.5–13)	4 (1.5–8.5)
Mean	4.4	4.2		4.0	4.6		4.3	4.5		4.6	4.3
CEA - ng/mL			0.057			0.703			0.491			1.000
0.0–5.0	87	63		26	61		39	48		49	38
> 5.0	53	21		14	39		27	26		30	23
N/A	2	3		1	1		0	2		0	2

P values were calculated with the use of χ² test or Fisher exact test for categorical variables and Kruskal-Wallis test for continuous variables
^a Reported as mucinous adenocarcinomas
N/A not available

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