| |
With any mutation
|
No mutation
|
P value
|
With APC mutation
|
With other mutation but no APC mutation
|
P value
|
With TP53 mutation
|
With other mutation but no TP53 mutation
|
P value
|
With RAS mutation
|
With other mutation but no RAS mutation
|
P value
|
|---|
|
Patients - no.
|
142
|
87
| |
41
|
101
| |
66
|
76
| |
79
|
63
| |
|
Age
|
|
Median (range) - yr
|
66 (40–90)
|
65 (31–87)
| |
64 (42–90)
|
67 (40–82)
| |
65 (44–82)
|
67 (40–90)
| |
65 (42–88)
|
67 (40–90)
| |
|
Mean - yr
|
66.3
|
65.2
| |
66.0
|
66.4
| |
65
|
67.4
| |
65.8
|
67.0
| |
|
< 50 - no.
|
11
|
9
|
0.508
|
5
|
6
|
0.845
|
5
|
6
|
0.185
|
5
|
6
|
0.517
|
|
50–70 - no.
|
77
|
47
| |
21
|
56
| |
40
|
37
| |
46
|
31
| |
|
> 70 - no.
|
54
|
31
| |
15
|
39
| |
21
|
33
| |
28
|
26
| |
|
Gender - no.
| | |
0.204
| | |
0.852
| | |
0.002
| | |
0.096
|
|
Male
|
85
|
60
| |
24
|
61
| |
49
|
36
| |
43
|
42
| |
|
Female
|
57
|
27
| |
17
|
40
| |
17
|
40
| |
36
|
21
| |
|
Clinical stage - no.
| | |
0.041
| | |
0.631
| | |
0.204
| | |
0.019
|
|
I
|
35
|
18
| |
12
|
23
| |
21
|
14
| |
24
|
11
| |
|
II
|
37
|
32
| |
12
|
25
| |
18
|
19
| |
13
|
24
| |
|
III
|
49
|
33
| |
11
|
38
| |
18
|
31
| |
31
|
18
| |
|
IV
|
21
|
4
| |
6
|
15
| |
9
|
12
| |
11
|
10
| |
|
Location sampled - no.
| | |
0.062
| | |
0.266
| | |
0.213
| | |
0.136
|
|
Rectum
|
117
|
60
| |
35
|
82
| |
57
|
60
| |
70
|
47
| |
|
Left Colon
|
8
|
11
| |
1
|
7
| |
2
|
6
| |
2
|
6
| |
|
Right Colon
|
9
|
12
| |
1
|
8
| |
2
|
7
| |
3
|
6
| |
|
Rectosigmoid Junction
|
8
|
4
| |
4
|
4
| |
5
|
3
| |
4
|
4
| |
|
Differentiation - no.
| | |
0.892
| | |
0.128
| | |
0.156
| | |
0.400
|
|
Well
|
8
|
5
| |
0
|
8
| |
5
|
3
| |
6
|
2
| |
|
Moderate
|
113
|
67
| |
36
|
77
| |
50
|
63
| |
60
|
53
| |
|
Poor
|
16
|
12
| |
3
|
13
| |
11
|
5
| |
10
|
6
| |
|
Unknowna
|
5
|
3
| |
2
|
3
| |
0
|
5
| |
3
|
2
| |
|
Metastasis- no.
| | |
0.017
| | |
1.000
| | |
0.815
| | |
0.814
|
|
With Metastasis
|
21
|
4
| |
6
|
15
| |
9
|
12
| |
11
|
10
| |
|
Without Metastasis
|
121
|
83
| |
35
|
86
| |
57
|
64
| |
68
|
53
| |
|
Treatment after surgery - no.
| | |
0.405
| | |
0.133
| | |
0.611
| | |
1.000
|
|
With adjuvant therapy
|
77
|
52
| |
26
|
51
| |
34
|
43
| |
42
|
35
| |
|
Without adjuvant therapy
|
63
|
33
| |
14
|
49
| |
31
|
32
| |
35
|
28
| |
|
N/A
|
2
|
2
| |
1
|
1
| |
1
|
1
| |
2
|
0
| |
|
Tumor size - cm
| | |
0.332
| | |
0.066
| | |
0.598
| | |
0.479
|
|
Median (range)
|
4 (1.5–13)
|
4 (1.5–10)
| |
4 (1.5–12)
|
4.3 (1.5–13)
| |
4 (1.5–11)
|
4 (1.5–13)
| |
4 (1.5–13)
|
4 (1.5–8.5)
| |
|
Mean
|
4.4
|
4.2
| |
4.0
|
4.6
| |
4.3
|
4.5
| |
4.6
|
4.3
| |
|
CEA - ng/mL
| | |
0.057
| | |
0.703
| | |
0.491
| | |
1.000
|
|
0.0–5.0
|
87
|
63
| |
26
|
61
| |
39
|
48
| |
49
|
38
| |
|
> 5.0
|
53
|
21
| |
14
|
39
| |
27
|
26
| |
30
|
23
| |
|
N/A
|
2
|
3
| |
1
|
1
| |
0
|
2
| |
0
|
2
| |
- P values were calculated with the use of χ2 test or Fisher exact test for categorical variables and Kruskal-Wallis test for continuous variables
- a Reported as mucinous adenocarcinomas
- N/A not available
