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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Biomarker discovery in attention deficit hyperactivity disorder: RNA sequencing of whole blood in discordant twin and case-controlled cohorts

Fig. 2

Schematic representation of analytical strategy and top hits. Two separate cohorts: ADHD Cases vs Control and ADHD Discordant Monozygotic Twins were analyzed for whole blood RNA levels by RNAseq. The data was analyzed by 9 distinct methods (i.e. EdgeR/com/glm/tcc, DESeq, etc.) and then differentially expressed genes (DEG) identified by multiple methods resulted in 391 transcripts for Case/Control of which 7 passed 8 or more filters. For discordant twins, 385 transcripts were identified of which 10 passed 8 or more filters. Comparing the 393 and 385 lists identified 5 transcripts identical in both cohorts

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BMC Medical Genomics

ISSN: 1755-8794

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