Fig. 4

a Kaplan Meier plots evaluating the impact of TP53 and CTNNB1 mutation on overall survival in the TCGA and in the NIH datasets. These can be compared to the Kaplan Meier plots derived from gene expression array data for aggressive C1A and indolent C1B subtypes [6, 8]. b Total number of mutations for each subgroup are graphically depicted with the mean and SD. The numbers in brackets below each dotplot are the mean number of mutations for that subgroup. Mutation counts in the ACC TCGA dataset are higher in tumors harboring a TP53 MUT compared to those with TP53WT [***p = 0.001], although many of those patients were also noted to have mutations suggestive of MMR deficiency (red symbols). The correlation with TP53 MUT was weaker in the smaller NIH dataset [*p = 0.05]. Orange symbols indicate that the mutation counts were additionally filtered by germline sequencing in those patients. None of the patients in the NIH set had germline TP53 mutations