From: In silico pathway analysis based on chromosomal instability in breast cancer patients
Type of aberration | Cases | Controls | p-value | ||
---|---|---|---|---|---|
Chromosomes/ chromosome arms involved | Frequency | Chromosomes/ chromosome arms involved | Frequency | ||
Loss | 5, 8,16, 17, 18, 19, 20, 21, 22, X | 78.8 ± 21.20 | 8, 9, 15, 17, 19, 20, 22, X | 57.25 ± 9.23 | 0.0169 |
Gain | 2, 3, 8, 9, X | 8.8 ± 4.6 | 3, 4, 6, 16, 21 | 9.8 ± 2.28 | 0.674 |
Break | 1p, 1q, 2p, 2q, 3q, 4p, 4q, 7q, 9q, 17q | 12.43 ± 5.29 | 1q, 2q, 3p, 3q, 4q, 16q | 4.4 ± 1.95 | 0.0065 |
Gap | 1p, 1q, 2p, 3p, 3q, 4q, 5q, 6q, 9q, 11q | 4.25 ± 2.19 | 1q, 2q, 5q, 14q, 17q | 1.8 ± 0.84 | 0.0334 |
Deletion | 1p, 1q, 2q, 3q, 4q, 5q, Xq | 7.2 ± 2.6 | 1p, 1q, 5p, 6q, Xp | 4.2 ± 1.1 | 0.0264 |
Addition | 1q, 9q | Â | 9q | NC | NC |
Translocations | 1, 5, 8, 10, 12, X | 4.83 ± 1.47 | 2, 4, 16 | 2.66 ± 0.57 | 0.0475 |
Robertsonian translocation | 15, 21 | 26.5 ± 7.78 | 13, 21, 22 | 26.33 ± 3.79 | 0.9749 |
Telomeric associations | 1, 2, 3, 12,16, 18, 19, 20 | 9.83 ± 3.37 | 7,19, X | 14.33 ± 4.04 | 0.1182 |
Acrocentric chromosomes:13, 14, 15, 21, 22 | 101 ± 14.73 | Acrocentric chromosomes: 13, 14, 15, 21, 22 | 44.8 ± 11.19 | 0.0008 | |
Triradials | 15, 21, 22 | 17 ± 5.29 | 14, 15, 21, 22 | 9.75 ± 2.36 | 0.0552 |