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Table 3 Comparison of frequency of chromosomes involved in various aberrations in the breast cancer patients and controls

From: In silico pathway analysis based on chromosomal instability in breast cancer patients

Type of aberration

Cases

Controls

p-value

Chromosomes/

chromosome arms involved

Frequency

Chromosomes/ chromosome

arms involved

Frequency

Loss

5, 8,16, 17, 18, 19, 20, 21, 22, X

78.8 ± 21.20

8, 9, 15, 17, 19, 20, 22, X

57.25 ± 9.23

0.0169

Gain

2, 3, 8, 9, X

8.8 ± 4.6

3, 4, 6, 16, 21

9.8 ± 2.28

0.674

Break

1p, 1q, 2p, 2q, 3q, 4p, 4q, 7q, 9q, 17q

12.43 ± 5.29

1q, 2q, 3p, 3q, 4q, 16q

4.4 ± 1.95

0.0065

Gap

1p, 1q, 2p, 3p, 3q, 4q, 5q, 6q, 9q, 11q

4.25 ± 2.19

1q, 2q, 5q, 14q, 17q

1.8 ± 0.84

0.0334

Deletion

1p, 1q, 2q, 3q, 4q, 5q, Xq

7.2 ± 2.6

1p, 1q, 5p, 6q, Xp

4.2 ± 1.1

0.0264

Addition

1q, 9q

 

9q

NC

NC

Translocations

1, 5, 8, 10, 12, X

4.83 ± 1.47

2, 4, 16

2.66 ± 0.57

0.0475

Robertsonian translocation

15, 21

26.5 ± 7.78

13, 21, 22

26.33 ± 3.79

0.9749

Telomeric associations

1, 2, 3, 12,16, 18, 19, 20

9.83 ± 3.37

7,19, X

14.33 ± 4.04

0.1182

Acrocentric chromosomes:13, 14, 15, 21, 22

101 ± 14.73

Acrocentric chromosomes: 13, 14, 15, 21, 22

44.8 ± 11.19

0.0008

Triradials

15, 21, 22

17 ± 5.29

14, 15, 21, 22

9.75 ± 2.36

0.0552

  1. Significant p-value (< 0.05), calculated by t-test, are shown in bold