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Table 1 The main GO and KEGG pathways involving NEK2 and its interacting proteins downloaded from STRING database

From: Involvement of NEK2 and its interaction with NDC80 and CEP250 in hepatocellular carcinoma

Categories Pathway ID Pathway description Gene count FDR Genes
Biological process (GO) GO:0007049 Cell cycle 7 2.78E-05 CEP250,MAD1L1,MAPK1,NDC80,NEK11,NEK2,PPP1CA
  GO:1901990 Regulation of mitotic cell cycle phase transition 5 4.01E-05 CEP250,MAD1L1,NDC80,NEK11,NEK2
  GO:1903047 Mitotic cell cycle process 5 0.00021 CEP250,MAD1L1,NDC80,NEK11,NEK2
Molecular function (GO) GO:0019902 Phosphatase binding 3 0.0026 MAPK1,NEK2,PPP1CA
  GO:0004674 Protein serine/threonine kinase activity 3 0.0219 MAPK1,NEK11,NEK2
  GO:0019903 Protein phosphatase binding 2 0.0265 NEK2,PPP1CA
Cellular component (GO) GO:0005815 Microtubule organizing center 5 0.00037 CEP250,MAD1L1,MAPK1,NDC80,NEK2
  GO:0005813 Centrosome 4 0.00059 CEP250,MAD1L1,NDC80,NEK2
  GO:0000777 Condensed chromosome kinetochore 3 0.00059 MAD1L1,NDC80,NEK2
KEGG pathways hsa04720 Long-term potentiation 2 0.0337 MAPK1,PPP1CA
  hsa04914 Progesterone-mediated oocyte maturation 2 0.0356 MAD1L1,MAPK1
  hsa04022 cGMP-PKG signaling pathway 2 0.0358 MAPK1,PPP1CA
  1. FDR false discovery rate