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Table 4 Cox regression model of clinical covariates and the NEK2, NDC80 and CEP250 mRNA expression for HCC patients’ survival

From: Involvement of NEK2 and its interaction with NDC80 and CEP250 in hepatocellular carcinoma

  Univariate analysis Multivariate analysis
HR 95% CI p value HR 95% CI p value
Age 1.012 0.998–1.026 0.091 1.016 1.000–1.032 0.045
Gender (ref. Female) 1.260 0.884–1.795 0.201    
Family history (ref. No) 0.828 0.574–1.195 0.314    
Recurrence (ref. No) 0.587 0.371–0.926 0.022    
Weight 0.993 0.984–1.003 0.195    
Platelet count 1.000 1.000–1.000 0.696    
Child–Pugh score (ref. A)
 B 0.469 0.064–3.408 0.454    
 C 0.747 0.092–6.055 0.785    
Histological grade (ref.G1)       
 G2 0.595 0.220–1.609 0.306    
 G3 0.692 0.277–1.731 0.431    
 G4 0.705 0.278–1.786 0.461    
Pathologic stage (ref.Stage I)
 Stage II 0.178 0.055–0.577 0.004 1.240 0.735–2.093 0.420
 Stage III 0.254 0.077–0.842 0.025 2.438 1.562–3.805 2.438
 Stage IV 0.492 0.152–1.590 0.236 7.033 2.152–22.979 0.001
Primary tumor range (ref.T1)
 T2 0.186 0.093–0.372  < 0.001    
 T3 0.267 0.129–0.550  < 0.001    
 T4 0.497 0.248–0.997 0.049    
NEK2 mRNA expression 1.001 1.000–1.001 0.001    
NDC80 mRNA expression 1.001 1.001–1.002  < 0.001 1.001 1.001–1.002  < 0.001
CEP250 mRNA expression 1.000 1.000–1.001 0.027    
  1. HR hazard ratio, CI confidence interval, Ref reference