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Table 4 Cox regression model of clinical covariates and the NEK2, NDC80 and CEP250 mRNA expression for HCC patients’ survival

From: Involvement of NEK2 and its interaction with NDC80 and CEP250 in hepatocellular carcinoma

 

Univariate analysis

Multivariate analysis

HR

95% CI

p value

HR

95% CI

p value

Age

1.012

0.998–1.026

0.091

1.016

1.000–1.032

0.045

Gender (ref. Female)

1.260

0.884–1.795

0.201

   

Family history (ref. No)

0.828

0.574–1.195

0.314

   

Recurrence (ref. No)

0.587

0.371–0.926

0.022

   

Weight

0.993

0.984–1.003

0.195

   

Platelet count

1.000

1.000–1.000

0.696

   

Child–Pugh score (ref. A)

 B

0.469

0.064–3.408

0.454

   

 C

0.747

0.092–6.055

0.785

   

Histological grade (ref.G1)

      

 G2

0.595

0.220–1.609

0.306

   

 G3

0.692

0.277–1.731

0.431

   

 G4

0.705

0.278–1.786

0.461

   

Pathologic stage (ref.Stage I)

 Stage II

0.178

0.055–0.577

0.004

1.240

0.735–2.093

0.420

 Stage III

0.254

0.077–0.842

0.025

2.438

1.562–3.805

2.438

 Stage IV

0.492

0.152–1.590

0.236

7.033

2.152–22.979

0.001

Primary tumor range (ref.T1)

 T2

0.186

0.093–0.372

 < 0.001

   

 T3

0.267

0.129–0.550

 < 0.001

   

 T4

0.497

0.248–0.997

0.049

   

NEK2 mRNA expression

1.001

1.000–1.001

0.001

   

NDC80 mRNA expression

1.001

1.001–1.002

 < 0.001

1.001

1.001–1.002

 < 0.001

CEP250 mRNA expression

1.000

1.000–1.001

0.027

   
  1. HR hazard ratio, CI confidence interval, Ref reference
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BMC Medical Genomics

ISSN: 1755-8794

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