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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Considering the APOE locus in Alzheimer’s disease polygenic scores in the Health and Retirement Study: a longitudinal panel study

Fig. 1

The APOE/TOMM40 genomic locus on chromosome 19. The y-axis corresponds to − log10(p-values) of association with Alzheimer’s disease in Kunkle et al. [6]. Single nucleotide polymorphisms within the bracketed genomic region were removed from consideration in polygenic score development for scores designed to exclude the APOE region. The variants that make the APOE isoforms are highlighted in purple diamond (rs7412, rs429358)

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