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Table 1 Individual and observation-level descriptive statistics in the Health and Retirement Study, n = 9871, m = 51225

From: Considering the APOE locus in Alzheimer’s disease polygenic scores in the Health and Retirement Study: a longitudinal panel study

 

Individuals

Male

Female

Overall

P†

n = 4141

n = 5676

n = 9817

Number of visits

5.0 (1.8)

5.4 (1.7)

5.2 (1.8)

 < .0001

Dementia at first visit, n (%)

121 (2.9)

135 (2.4)

256 (2.6)

0.1

Age (yrs) first visit

63.7 (9.7)

63.0 (10.8)

63.3 (10.3)

 < .001

Education (yrs)

13.4 (2.7)

13.1 (2.4)

13.2 (2.5)

 < .0001

HRS Cohort, n (%)

   

 < .0001

AHEAD

756 (13.3)

310 (7.5)

1066 (10.9)

 

CODA

552 (9.7)

348 (8.4)

900 (9.2)

 

HRS

2573 (45.3)

1928 (46.6)

4501 (45.9)

 

WB

625 (11)

529 (12.8)

1154 (11.8)

 

EBB

793 (14)

690 (16.7)

1483 (15.1)

 

MBB

377 (6.6)

336 (8.1)

713 (7.3)

 

Stroke at first visit, n (%)

201 (4.9)

216 (3.8)

417 (4.3)

0.01

APOE-ε4, n (%)

   

0.98

No copies

3051 (73.7)

4174 (73.5)

7225 (73.6)

 

One copy

1001 (24.2)

1381 (24.3)

2382 (24.3)

 

Two copies

89 (2.1)

121 (2.1)

210 (2.1)

 

AD PGS

    

With APOE region‡

    

 pT = 0.001

0.01 (1.0)

 − 0.02 (1.0)

 − 0.01 (1.0)

0.51

 pT = 0.01

0.00 (1.0)

 − 0.02 (1.0)

 − 0.01 (1.0)

0.40

 pT = 0.05

 − 0.01 (1.0)

 − 0.02 (1.0)

 − 0.02 (1.0)

0.50

 pT = 0.1

 − 0.01 (1.0)

 − 0.02 (1.0)

 − 0.02 (1.0)

0.47

 pT = 0.3

 − 0.02 (1.0)

 − 0.02 (1.0)

 − 0.02 (1.0)

0.87

 pT = 1

 − 0.01 (1.0)

 − 0.02 (1.0)

 − 0.02 (1.0)

0.71

Without APOE region‡

    

 pT = 0.001

0.01 (1.0)

 − 0.02 (1.0)

 − 0.01 (1.0)

0.36

 pT = 0.01

0.00 (1.0)

 − 0.02 (1.0)

 − 0.01 (1.0)

0.42

 pT = 0.05

 − 0.01 (1.0)

 − 0.02 (1.0)

 − 0.01 (1.0)

0.52

 pT = 0.1

 − 0.01 (1.0)

 − 0.02 (1.0)

 − 0.02 (1.0)

0.48

 pT = 0.3

 − 0.02 (1.0)

 − 0.02 (1.0)

 − 0.02 (1.0)

0.88

 pT = 1

 − 0.01 (1.0)

 − 0.02 (1.0)

 − 0.02 (1.0)

0.72

 

Observations

Male

Female

Overall

 

m = 20,802

m = 30,423

m = 51,225

P§

Dementia, n (%)

785 (3.8)

1078 (3.5)

1863 (3.6)

0.35

Age (yrs)

68.1 (9.8)

67.6 (10.7)

67.8 (10.3)

0.45

Stroke, n (%)

1422 (6.8)

1594 (5.2)

3016 (5.9)

0.0004

Year, n (%)

   

0.62

2002

4002 (59.9)

2682 (40.1)

6684 (13.1)

 

2004

4658 (58.9)

3253 (41.1)

7911 (15.4)

 

2006

4652 (59.0)

3230 (41.0)

7882 (15.4)

 

2008

4531 (59.2)

3122 (40.8)

7653 (14.9)

 

2010

4520 (59.1)

3128 (40.9)

7648 (14.9)

 

2012

4204 (59.7)

2841 (40.3)

7045 (13.8)

 

2014

3856 (60.2)

2546 (39.8)

6402 (12.5)

 
  1. SD: standard deviation; AHEAD: Asset and Health Dynamics Among the Oldest Old (b. < 1924); CODA: Children of the Depression (b. 1924–1930); HRS: Health and Retirement Study—original cohort (b. 1931–1941); WB: War babies (b. 1942–1947); EBB: early baby boomers (b. 1948–1953); MBB: mid-baby boomers (b. 1954–1959); AD: Alzheimer’s disease; PGS: Polygenic score; pT: P-value threshold for SNP-outcome association from the Alzheimer’s disease meta-analysis for inclusion into the polygenic score. Means and (standard deviations) are reported unless otherwise noted
  2. †P-values are for tests of mean difference (t-test) or difference in distribution (chi-square), by sex
  3. §P-values for dementia and stroke are from a repeated measures model with a binary distribution and logit link, unstructured correlation structure and repeated individual model to test for differences by sex. For Age, a two-step process where the mean age for each person across all visits was calculated, and then a t-test was performed on the resulting individual-means by sex
  4. ‡APOE region defined as chromosome 19 (45,384,477 to 45,432,606, build 37/hg 19). This represents the start position of TOMM40 (45,394,477) − 10 KB and the stop position of APOC1 (45,422,606) + 10 KB
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BMC Medical Genomics

ISSN: 1755-8794

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