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Table 2 Odds ratios from repeated measures generalized linear models regression analyses of dementia in the Health and Retirement Study, n = 9871, m = 51,225

From: Considering the APOE locus in Alzheimer’s disease polygenic scores in the Health and Retirement Study: a longitudinal panel study

 

pT = 0.001

pT = 0.01

pT = 0.05

pT = 0.1

pT = 0.3

pT = 1.0

OR (SE)

95% CI

P

OR (SE)

95% CI

P

OR (SE)

95% CI

P

OR (SE)

95% CI

P

OR (SE)

95% CI

P

OR (SE)

95% CI

P

Polygenic score with APOE region†

Age (yrs)

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

Sex (male)

1.13 (1.08)

[0.96, 1.32]

0.131

1.13 (1.08)

[0.96, 1.32]

0.132

1.13 (1.08)

[0.96, 1.32]

0.143

1.12 (1.08)

[0.96, 1.32]

0.148

1.12 (1.08)

[0.96, 1.32]

0.147

1.12 (1.08)

[0.96, 1.32]

0.149

Educational (yrs)

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

Year

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

Stroke

3.36 (1.10)

[2.81, 4.01]

 < .0001

3.37 (1.10)

[2.82, 4.02]

 < .0001

3.36 (1.10)

[2.81, 4.02]

 < .0001

3.36 (1.10)

[2.81, 4.02]

 < .0001

3.37 (1.10)

[2.82, 4.03]

 < .0001

3.37 (1.10)

[2.82, 4.03]

 < .0001

No copies of APOE ε4

−

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

One copy of APOE ε4

2.10 (1.10)

[1.74, 2.52]

 < .0001

2.12 (1.09)

[1.78, 2.53]

 < .0001

2.18 (1.09)

[1.83, 2.59]

 < .0001

2.18 (1.09)

[1.84, 2.60]

 < .0001

2.20 (1.09)

[1.85, 2.61]

 < .0001

2.20 (1.09)

[1.85, 2.62]

 < .0001

Two copies of APOE ε4

4.38 (1.26)

[2.80, 6.85]

 < .0001

4.48 (1.25)

[2.90, 6.94]

 < .0001

4.72 (1.25)

[3.07, 7.26]

 < .0001

4.77 (1.25)

[3.11, 7.34]

 < .0001

4.84 (1.25)

[3.15, 7.44]

 < .0001

4.86 (1.25)

[3.16, 7.48]

 < .0001

AD polygenic score

1.06 (1.04)

[0.98, 1.16]

0.157

1.08 (1.04)

[1.00, 1.17]

0.064

1.07 (1.04)

[0.98, 1.16]

0.136

1.07 (1.04)

[0.98, 1.17]

0.124

1.07 (1.05)

[0.98, 1.17]

0.132

1.06 (1.05)

[0.97, 1.16]

0.166

Polygenic score without APOE region†

Age (yrs)

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

1.15 (1.01)

[1.14, 1.16]

 < .0001

Sex (male)

1.13 (1.08)

[0.97, 1.32]

0.124

1.13 (1.08)

[0.97, 1.32]

0.129

1.13 (1.08)

[0.96, 1.32]

0.142

1.12 (1.08)

[0.96, 1.32]

0.148

1.12 (1.08)

[0.96, 1.32]

0.147

1.12 (1.08)

[0.96, 1.32]

0.149

Educational (yrs)

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

0.76 (1.02)

[0.74, 0.79]

 < .0001

Year

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

1.12 (1.01)

[1.10, 1.14]

 < .0001

Stroke

3.36 (1.09)

[2.81, 4.01]

 < .0001

3.37 (1.10)

[2.82, 4.02]

 < .0001

3.36 (1.10)

[2.81, 4.01]

 < .0001

3.36 (1.10)

[2.81, 4.02]

 < .0001

3.37 (1.10)

[2.82, 4.02]

 < .0001

3.37 (1.10)

[2.82, 4.02]

 < .0001

No copies of APOE ε4

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

One copy of APOE ε4

2.16 (1.09)

[1.82, 2.56]

 < .0001

2.18 (1.09)

[1.83, 2.59]

 < .0001

2.2 (1.09)

[1.85, 2.62]

 < .0001

2.21 (1.09)

[1.86, 2.62]

 < .0001

2.21 (1.09)

[1.86, 2.63]

 < .0001

2.21 (1.09)

[1.86, 2.63]

 < .0001

Two copies of APOE ε4

4.64 (1.24)

[3.03, 7.11]

 < .0001

4.72 (1.24)

[3.07, 7.25]

 < .0001

4.84 (1.25)

[3.15, 7.43]

 < .0001

4.87 (1.25)

[3.17, 7.49]

 < .0001

4.91 (1.25)

[3.19, 7.55]

 < .0001

4.92 (1.25)

[3.20, 7.56]

 < .0001

AD polygenic score

1.09 (1.04)

[1.00, 1.17]

0.038

1.09 (1.04)

[1.01, 1.18]

0.028

1.07 (1.04)

[0.99, 1.17]

0.095

1.08 (1.04)

[0.99, 1.17]

0.094

1.07 (1.05)

[0.98, 1.17]

0.111

1.07 (1.05)

[0.98, 1.16]

0.144

  1. All models were additionally adjusted for five ancestry-specific principal components. Generalized linear models accounted for repeated measures by individual and used a binomial distribution, logit link, and unstructured correlation structure
  2. OR: Odds ratio estimate for dementia relative to normal cognition; SE: standard error; CI: confidence interval; P: P-value for the OR estimate; APOE: Apolipoprotein E; AD: Alzheimer’s disease; pT: P-value threshold for SNP-outcome association from the Alzheimer’s disease meta-analysis for inclusion into the polygenic score
  3. †APOE region defined as chromosome 19 (45,384,477 to 45,432,606, build 37/hg 19). This represents the start position of TOMM40 (45,394,477) − 10 KB and the stop position of APOC1 (45,422,606) + 10 KB
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BMC Medical Genomics

ISSN: 1755-8794

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