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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Genomic analysis of circular RNAs in heart

Fig. 3

Identification of dysregulated circRNAs in DCM. a Volcano plot showing differentially expressed circRNAs in DCM as compared to normal samples (p < 0.05 and Fold Change (FC) > 2). b Enriched pathway analysis for the host genes of the significantly differentially expressed circRNAs. ARVC: arrhythmogenic right ventricular cardiomyopathy. c Down-regulation of 2 rt-circRNAs originated from SCAF8 and TIAM2 gene including SCAF8_e4:TIAM2_e1 and SCAF8_e4:TIAM2_e2 in DCM. d Correlation of log2 FC of circRNA versus log2 FC of linear RNA expression. e Examples of significantly up- and down-regulated circRNAs with expression that is dependent or f independent of their host genes. *p < 0.05 (edgeR)

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