Fig. 4

Prediction of circRNA potential for sponging miRNAs. a Predicted circRNA-miRNA-circRNA regulatory network. High-abundance circRNAs with at least 5 predicted binding sites (BS) for at least 1 heart disease-related miRNA were included (n = 142). b Heatmap showing the number of BS of circRNAs with at least 10 BS for at least one heart disease-related miRNA. c Schematic diagram of circALMS1_6 which was predicted to have the strongest potential to sponge miR-133. d Schematic diagram of the rt-circRNA, circSCAF8_e4:TIAM2_e2, which was predicted to have potential to sponge multiple heart disease-related miRNAs. Colored rectangles indicate exons and the numbers within them represent the ID of exons. e Expression of miR-17 target genes in normal vs DCM human hearts. *p < 0.05 (edgeR)