TY - JOUR AU - Cheng, Jack AU - Liu, Hsin-Ping AU - Lin, Wei-Yong AU - Tsai, Fuu-Jen PY - 2020 DA - 2020/11/23 TI - Identification of contributing genes of Huntington’s disease by machine learning JO - BMC Medical Genomics SP - 176 VL - 13 IS - 1 AB - Huntington’s disease (HD) is an inherited disorder caused by the polyglutamine (poly-Q) mutations of the HTT gene results in neurodegeneration characterized by chorea, loss of coordination, cognitive decline. However, HD pathogenesis is still elusive. Despite the availability of a wide range of biological data, a comprehensive understanding of HD’s mechanism from machine learning is so far unrealized, majorly due to the lack of needed data density. SN - 1755-8794 UR - https://doi.org/10.1186/s12920-020-00822-w DO - 10.1186/s12920-020-00822-w ID - Cheng2020 ER -