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Table 2 Number of variants stratified by histologic subtype

From: Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups

 

All (N = 47)

EAC (N = 34)

USC (N = 13)

p-value

Unfiltered somatic variants

67 (57, 86)

71 (60, 90)

63 (56, 72)

0.11

Unfiltered somatic SNVs

63 (54, 79)

65 (55, 85)

58 (53, 69)

0.19

SNV C > A

6 (4, 9)

6.5 (4, 9)

5 (4, 8)

0.41

SNV C > G

2 (1, 3)

2 (1, 3)

2 (2, 3)

0.33

SNV C > T

9 (5, 13)

10 (8, 15)

6 (5, 7)

 < 0.01

SNV T > A

4 (2, 6)

4 (2, 6)

4 (3, 5)

0.75

SNV T > C

7 (4, 10)

7 (4, 11)

5 (4, 8)

0.35

SNV T > G

4 (3, 7)

4 (3, 7)

4 (3, 6)

0.39

Filtered somatic SNVs

8 (4, 14)

9 (7, 16)

3 (3, 8)

 < 0.01

Filtered somatic INDELs

2 (0, 3)

2 (1, 3)

1 (0, 3)

0.33

Pathogenic somatic variants

1 (0, 2)

1 (1,2)

0 (0, 1)

0.06

Candidate somatic variants of potential pathogenic interest

5 (3, 10)

6 (4, 13)

2 (2, 3)

 < 0.01

Pathogenic somatic variants plus candidate somatic variants of potential pathogenic interest

6 (3, 10)

7 (5, 14)

3 (2, 4)

 < 0.01

PTEN mutation [N(%)]

30 (63.8)

28 (82.4)

2 (15.4)

 < 0.01

PIK3CA mutation [N(%)]

28 (59.6)

25 (73.5)

3 (23.1)

 < 0.01

TP53 mutation [N(%)]

16 (34.0)

6 (17.7)

10 (76.9)

 < 0.01