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Table 2 Number of variants stratified by histologic subtype

From: Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups

  All (N = 47) EAC (N = 34) USC (N = 13) p-value
Unfiltered somatic variants 67 (57, 86) 71 (60, 90) 63 (56, 72) 0.11
Unfiltered somatic SNVs 63 (54, 79) 65 (55, 85) 58 (53, 69) 0.19
SNV C > A 6 (4, 9) 6.5 (4, 9) 5 (4, 8) 0.41
SNV C > G 2 (1, 3) 2 (1, 3) 2 (2, 3) 0.33
SNV C > T 9 (5, 13) 10 (8, 15) 6 (5, 7)  < 0.01
SNV T > A 4 (2, 6) 4 (2, 6) 4 (3, 5) 0.75
SNV T > C 7 (4, 10) 7 (4, 11) 5 (4, 8) 0.35
SNV T > G 4 (3, 7) 4 (3, 7) 4 (3, 6) 0.39
Filtered somatic SNVs 8 (4, 14) 9 (7, 16) 3 (3, 8)  < 0.01
Filtered somatic INDELs 2 (0, 3) 2 (1, 3) 1 (0, 3) 0.33
Pathogenic somatic variants 1 (0, 2) 1 (1,2) 0 (0, 1) 0.06
Candidate somatic variants of potential pathogenic interest 5 (3, 10) 6 (4, 13) 2 (2, 3)  < 0.01
Pathogenic somatic variants plus candidate somatic variants of potential pathogenic interest 6 (3, 10) 7 (5, 14) 3 (2, 4)  < 0.01
PTEN mutation [N(%)] 30 (63.8) 28 (82.4) 2 (15.4)  < 0.01
PIK3CA mutation [N(%)] 28 (59.6) 25 (73.5) 3 (23.1)  < 0.01
TP53 mutation [N(%)] 16 (34.0) 6 (17.7) 10 (76.9)  < 0.01