| All (N = 47) | EAC (N = 34) | USC (N = 13) | p-value |
---|---|---|---|---|
Unfiltered somatic variants | 67 (57, 86) | 71 (60, 90) | 63 (56, 72) | 0.11 |
Unfiltered somatic SNVs | 63 (54, 79) | 65 (55, 85) | 58 (53, 69) | 0.19 |
SNV C > A | 6 (4, 9) | 6.5 (4, 9) | 5 (4, 8) | 0.41 |
SNV C > G | 2 (1, 3) | 2 (1, 3) | 2 (2, 3) | 0.33 |
SNV C > T | 9 (5, 13) | 10 (8, 15) | 6 (5, 7) |  < 0.01 |
SNV T > A | 4 (2, 6) | 4 (2, 6) | 4 (3, 5) | 0.75 |
SNV T > C | 7 (4, 10) | 7 (4, 11) | 5 (4, 8) | 0.35 |
SNV T > G | 4 (3, 7) | 4 (3, 7) | 4 (3, 6) | 0.39 |
Filtered somatic SNVs | 8 (4, 14) | 9 (7, 16) | 3 (3, 8) |  < 0.01 |
Filtered somatic INDELs | 2 (0, 3) | 2 (1, 3) | 1 (0, 3) | 0.33 |
Pathogenic somatic variants | 1 (0, 2) | 1 (1,2) | 0 (0, 1) | 0.06 |
Candidate somatic variants of potential pathogenic interest | 5 (3, 10) | 6 (4, 13) | 2 (2, 3) |  < 0.01 |
Pathogenic somatic variants plus candidate somatic variants of potential pathogenic interest | 6 (3, 10) | 7 (5, 14) | 3 (2, 4) |  < 0.01 |
PTEN mutation [N(%)] | 30 (63.8) | 28 (82.4) | 2 (15.4) |  < 0.01 |
PIK3CA mutation [N(%)] | 28 (59.6) | 25 (73.5) | 3 (23.1) |  < 0.01 |
TP53 mutation [N(%)] | 16 (34.0) | 6 (17.7) | 10 (76.9) |  < 0.01 |