| All (N = 47) | Grade 1 EAC (N = 12) | Grade 2 EAC (N = 10) | Grade 3 EAC (N = 12) | USC (N = 13) | p-value |
---|---|---|---|---|---|---|
Unfiltered somatic variants | 67 (57, 86) | 64.5 (55.5, 71.5) | 74.5 (61, 82) | 139 (66, 346.5) | 63 (56, 72) | 0.03 |
Unfiltered somatic SNVs | 63 (54, 79) | 60 (52.5, 67.5) | 72 (59, 79) | 132 (58, 340) | 58 (53, 69) | 0.18 |
SNV C > A | 6 (4, 9) | 5.5 (3.5, 7.5) | 5.5 (4, 8) | 10.5 (5, 63) | 5 (4, 8) | 0.16 |
SNV C > G | 2 (1, 3) | 2.5 (1, 3.5) | 1 (1, 2) | 2.5 (1, 3) | 2 (2, 3) | 0.39 |
SNV C > T | 9 (5, 13) | 9.5 (8.5, 12.5) | 8.5 (5, 12) | 15.5 (9, 49.5) | 6 (5, 7) |  < 0.01 |
SNV T > A | 4 (2, 6) | 3 (2.5, 4) | 5.5 (2, 7) | 4.5 (2.5, 6.5) | 4 (3, 5) | 0.33 |
SNV T > C | 7 (4, 10) | 5.5 (3, 6.5) | 7.5 (6, 12) | 10.5 (7, 19.5) | 5 (4, 8) | 0.04 |
SNV T > G | 4 (3, 7) | 4 (2, 4) | 7 (5, 8) | 5.5 (3, 18) | 4 (3, 6) | 0.08 |
Filtered somatic SNVs | 8 (4, 14) | 8 (7, 9) | 7 (5, 16) | 56.5 (8.5, 202.5) | 3 (3, 8) |  < 0.01 |
Filtered somatic INDELs | 2 (0, 3) | 1 (1, 2) | 1.5 (1, 3) | 2.5 (1.5, 4) | 1 (0, 3) | 0.36 |
Pathogenic somatic variants | 1 (0, 2) | 1 (1, 2) | 0.5 (0, 1) | 1.5 (1, 3) | 0 (0, 1) |  < 0.01 |
Candidate somatic variants of potential pathogenic interest | 5 (3, 10) | 5 (4, 7) | 4 (4, 13) | 25 (6, 89.5) | 2 (2, 3) |  < 0.01 |
Pathogenic somatic variants plus candidate somatic variants of potential pathogenic interest | 6 (3, 10) | 6.5 (5, 7.5) | 5 (4, 14) | 26.5 (7, 92.5) | 3 (2, 4) |  < 0.01 |
PTEN mutation [N(%)] | 30 (63.8) | 10 (83.3) | 7 (70.0) | 11 (91.7) | 2 (15.4) |  < 0.01 |
PIK3CA mutation [N(%)] | 28 (59.6) | 8 (66.7) | 7 (70.0) | 10 (83.3) | 3 (23.1) | 0.01 |
TP53 mutation [N(%)] | 16 (34.0) | 0 (0) | 2 (20) | 4 (33.3) | 10 (76.9) |  < 0.01 |