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Table 3 Number of variants stratified by histologic subtype and grade

From: Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups

  All (N = 47) Grade 1 EAC (N = 12) Grade 2 EAC (N = 10) Grade 3 EAC (N = 12) USC (N = 13) p-value
Unfiltered somatic variants 67 (57, 86) 64.5 (55.5, 71.5) 74.5 (61, 82) 139 (66, 346.5) 63 (56, 72) 0.03
Unfiltered somatic SNVs 63 (54, 79) 60 (52.5, 67.5) 72 (59, 79) 132 (58, 340) 58 (53, 69) 0.18
SNV C > A 6 (4, 9) 5.5 (3.5, 7.5) 5.5 (4, 8) 10.5 (5, 63) 5 (4, 8) 0.16
SNV C > G 2 (1, 3) 2.5 (1, 3.5) 1 (1, 2) 2.5 (1, 3) 2 (2, 3) 0.39
SNV C > T 9 (5, 13) 9.5 (8.5, 12.5) 8.5 (5, 12) 15.5 (9, 49.5) 6 (5, 7)  < 0.01
SNV T > A 4 (2, 6) 3 (2.5, 4) 5.5 (2, 7) 4.5 (2.5, 6.5) 4 (3, 5) 0.33
SNV T > C 7 (4, 10) 5.5 (3, 6.5) 7.5 (6, 12) 10.5 (7, 19.5) 5 (4, 8) 0.04
SNV T > G 4 (3, 7) 4 (2, 4) 7 (5, 8) 5.5 (3, 18) 4 (3, 6) 0.08
Filtered somatic SNVs 8 (4, 14) 8 (7, 9) 7 (5, 16) 56.5 (8.5, 202.5) 3 (3, 8)  < 0.01
Filtered somatic INDELs 2 (0, 3) 1 (1, 2) 1.5 (1, 3) 2.5 (1.5, 4) 1 (0, 3) 0.36
Pathogenic somatic variants 1 (0, 2) 1 (1, 2) 0.5 (0, 1) 1.5 (1, 3) 0 (0, 1)  < 0.01
Candidate somatic variants of potential pathogenic interest 5 (3, 10) 5 (4, 7) 4 (4, 13) 25 (6, 89.5) 2 (2, 3)  < 0.01
Pathogenic somatic variants plus candidate somatic variants of potential pathogenic interest 6 (3, 10) 6.5 (5, 7.5) 5 (4, 14) 26.5 (7, 92.5) 3 (2, 4)  < 0.01
PTEN mutation [N(%)] 30 (63.8) 10 (83.3) 7 (70.0) 11 (91.7) 2 (15.4)  < 0.01
PIK3CA mutation [N(%)] 28 (59.6) 8 (66.7) 7 (70.0) 10 (83.3) 3 (23.1) 0.01
TP53 mutation [N(%)] 16 (34.0) 0 (0) 2 (20) 4 (33.3) 10 (76.9)  < 0.01