Table 4 Number of variants stratified by low versus high tumor mutational burden
|  | All (N = 47) | Non-hypermutated (N = 41) | Hypermutated (N = 6) | p-value |
|---|---|---|---|---|
Unfiltered somatic variants | 67 (57, 86) | 65 (56, 76) | 346.5 (209, 402) |  < 0.01 |
Unfiltered somatic SNVs | 63 (54, 79) | 61 (53, 73) | 340 (193, 399) |  < 0.01 |
SNV C > A | 6 (4, 9) | 5 (4, 8) | 63 (37, 81) |  < 0.01 |
SNV C > G | 2 (1, 3) | 2 (1, 3) | 3 (2, 3) | 0.58 |
SNV C > T | 9 (5, 13) | 8 (5, 12) | 49.5 (31, 95) |  < 0.01 |
SNV T > A | 4 (2, 6) | 4 (2, 5) | 5.5 (4, 7) | 0.30 |
SNV T > C | 7 (4, 10) | 6 (4, 8) | 19.5 (15, 22) |  < 0.01 |
SNV T > G | 4 (3, 7) | 4 (3, 6) | 18 (11, 27) |  < 0.01 |
Filtered somatic SNVs | 8 (4, 14) | 7 (4, 9) | 202.5 (105, 234) |  < 0.01 |
Filtered somatic INDELs | 2 (0, 3) | 2 (0, 3) | 2 (1, 3) | 0.57 |
Pathogenic somatic variants | 1 (0, 2) | 1 (0, 1) | 3 (2, 6) |  < 0.01 |
Candidate somatic variants of potential pathogenic interest | 5 (3, 10) | 4 (2, 7) | 89.5 (43, 119) |  < 0.01 |
Pathogenic somatic variants plus candidate somatic variants of potential pathogenic interest | 6 (3, 10) | 5 (3, 8) | 92.5 (45, 125) |  < 0.01 |