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Table 4 Number of variants stratified by low versus high tumor mutational burden

From: Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups

  All (N = 47) Non-hypermutated (N = 41) Hypermutated (N = 6) p-value
Unfiltered somatic variants 67 (57, 86) 65 (56, 76) 346.5 (209, 402)  < 0.01
Unfiltered somatic SNVs 63 (54, 79) 61 (53, 73) 340 (193, 399)  < 0.01
SNV C > A 6 (4, 9) 5 (4, 8) 63 (37, 81)  < 0.01
SNV C > G 2 (1, 3) 2 (1, 3) 3 (2, 3) 0.58
SNV C > T 9 (5, 13) 8 (5, 12) 49.5 (31, 95)  < 0.01
SNV T > A 4 (2, 6) 4 (2, 5) 5.5 (4, 7) 0.30
SNV T > C 7 (4, 10) 6 (4, 8) 19.5 (15, 22)  < 0.01
SNV T > G 4 (3, 7) 4 (3, 6) 18 (11, 27)  < 0.01
Filtered somatic SNVs 8 (4, 14) 7 (4, 9) 202.5 (105, 234)  < 0.01
Filtered somatic INDELs 2 (0, 3) 2 (0, 3) 2 (1, 3) 0.57
Pathogenic somatic variants 1 (0, 2) 1 (0, 1) 3 (2, 6)  < 0.01
Candidate somatic variants of potential pathogenic interest 5 (3, 10) 4 (2, 7) 89.5 (43, 119)  < 0.01
Pathogenic somatic variants plus candidate somatic variants of potential pathogenic interest 6 (3, 10) 5 (3, 8) 92.5 (45, 125)  < 0.01