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Table 5 Mutations mapping to POLE

From: Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups

Amino acid change Coding EC hypermutated EC NON hypermutated Control blood
p.Ter2287Trp c.6860A > G             
p.Leu2274Val c.6820C > G             
p.Glu2140Lys c.6418G > A             
p.Ile1864Ser c.5591 T > G             
p.Asp1211Gly c.3632A > G             
p.Asp530Asn c.1588G > A             
p.Ala456Val c.1367C > T             
p.Val411Leu c.1231G > T             
p.Asn151Lys c.453 T > G             
p.Leu98Val c.292 T > G            
p.Ala252Val c.755C > T            
p.Asn1396Ser c.4187A > G             
p.Pro286Arg c.857C > G          
Pathogenic variants 5 0 0
Unknown significance in functional domains 3 0 0
Unknown significance outside functional domains 4 0 0
Benign in functional domains 4 2 0
TOT number exonic variants 16 2 1