Table 2 Fifteen differently expressed genes in whole blood of OI patients

IFI27

Interferon, alpha-inducible protein 27

Adaptor protein involved into IFN type-I -induced apoptosis

1.70E−29

4.00E−25

MTRNR2L1

MT-RNR2-like 1

Neuroprotective, antiapoptotic factor

3.50E−28

4.00E−24

RAP1GAP

RAP1 GTPase activating protein

GTPase activator

3.30E−21

3.00E−17

ADGRG7

Adhesion G Protein-Coupled Receptor G7

Transmembrane signaling

4.00E−19

2.00E−15

RSAD2

Radical S-adenosyl methionine domain containing 2

Antiviral state induced with IFN type I and II

1.90E−17

9.00E−14

IFI44L

Interferon-induced protein 44-like

Antiviral activity

6.70E−17

3.00E−13

LTF

Lactoferrin (Lactotransferrin)

Iron binding protein. Anabolic, differentiating and anti-apoptotic effects on osteoblasts, inhibits osteoclastogenesis, possibly playing a role in the regulation of bone growth

2.00E−15

7.00E−12

JCHAIN

Immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

Serves to link two monomer units of either IgM or IgA

2.80E−15

9.00E−12

ALAS2

Aminolevulinate, delta-, synthase 2

Enzyme, participates in Gly, Ser, Thr metabolism

5.10E−15

1.00E−11

IFITM3

Interferon-induced transmembrane protein 3

Antiviral protein, involved in vacuolar ATPase structural stability

2.00E−14

5.00E−11

RNF182

Ring finger protein 182

E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C

3.20E−14

7.00E−11

MMP8

Matrix metallopeptidase 8 (neutrophil collagenase)

Cleavage of interstitial collagens in the triple helical domain, collagen type I degradation

3.50E−14

7.00E−11

DEFA3

Defensin Alpha 3

Antimicrobial and cytotoxic peptide involved in host defense

1.10E−11

2.00E−08

DEFA1B_dup3

-

-

1.10E−11

2.00E−08

DEFA1_dup3

-

-

1.10E−11

2.00E−08

OLFM4

Olfactomedin 4

In myeloid leukemia cell lines, inhibits cell growth and induces cell differentiation and apoptosis

4.50E−10

5.00E−07

BCORP1

BCL6 corepressor pseudogene 1

Pseudogene

7.20E−08

5.00E−05

RIMBP2

RIMS binding protein 2

Plays a role in the synaptic transmission as bifunctional linker

8.20E−07

5.00E−04

PNMA8A

Paraneoplastic Ma antigen family-like 1

Gene associated with oligodendroglioma

1.90E−06

1.00E−03

CELA1

Chymotrypsin-like elastase family, member 1

Hydrolysis of proteins, including elastin

2.50E−06

1.00E−03

SHCBP1

SHC SH2-domain binding protein 1

Testis-specific spindle-associated factor that plays a role in spermatogenesis

5.20E−06

2.00E−03

ZC3HAV1L

Zinc finger CCCH-type, antiviral 1-like

Antiviral protein

1.00E−05

4.00E−03

UBE2C

Ubiquitin-conjugating enzyme E2C

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins

1.30E−05

5.00E−03

NEK8

NIMA-related kinase 8

Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells

1.40E−05

5.00E−03

SDC1

Syndecan 1

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix

1.60E−05

6.00E−03

CEACAM6

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)

Cell surface glycoprotein that plays a role in cell adhesion and tumor progression

1.80E−05

6.00E−03

TCL6

T-cell leukemia/lymphoma 6 (non-protein coding)

RNA Gene, and is affiliated with the misc_RNA class. May have a function in neuronal differentiation and/or axon growth

2.80E−05

9.00E−03

ZBTB32

Zinc finger and BTB domain containing 32

DNA-binding protein. May function as a transcriptional transactivator and transcriptional repressor

2.90E−05

9.00E−03

GBP7

Guanylate binding protein 7

GTP to GMP hydrolysis

3.20E−05

1.00E−02

STOX1

Storkhead box 1

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species

5.30E−05

1.60E−02

KCNN3

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

Forms a voltage-independent potassium channel activated by intracellular calcium

7.00E−05

2.00E−02

TM4SF19

Transmembrane 4 L six family member 19

Members of this family function in various cellular processes, including cell proliferation, motility, and adhesion via their interactions with integrins

9.70E−05

2.60E−02

DKK3

Dickkopf Wnt signaling pathway inhibitor 3

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt

9.90E−05

2.60E−02

GLDC

Glycine dehydrogenase (decarboxylating)

The glycine cleavage system catalyzes the degradation of glycine

1.00E−04

2.70E−02

LOC400931

–

–

1.40E−04

3.30E−02

GFPT2

Glutamine-fructose-6-phosphate transaminase 2

Controls the flux of glucose into the hexosamine pathway

1.40E−04

3.40E−02

MDGA1

MAM domain containing glycosylphosphatidylinositol anchor 1

Plays a role in the formation or maintenance of inhibitory synapses

1.60E−04

3.80E−02

G0S2

G0/G1 switch 2

Promotes apoptosis

1.80E−04

4.20E−02

SLC1A7

Solute carrier family 1 (glutamate transporter), member 7

Transports L-glutamate

2.20E−04

4.70E−02