Fig. 2
Promiscuity correction of differentially expressed genes across the pathways. a The percentage of differentially expressed genes (DEGs) associated with various pathways in all DEGs. X-axis denotes the number of pathways. Y-axis denotes the percentage of DEGs linking with certain pathways in all DEGs. b The percentage of DEGs and non-DEGs in pathway genes. The red bar indicates the percentage of DEGs relating to a specific pathway in pathway genes. The blue bar indicates the percentage of non-DEGs in pathway genes. The green bar indicates the percentage of DEGs participating in multiple pathways in pathway genes, which were then subjected to promiscuity correction. c Non corrected and d promiscuity-corrected t-values of DEGs within certain pathways. Each column represents a pathway and each dot represents a gene. The value of each dot represents the c Non corrected and d promiscuity-corrected mean t-values of cancer vs normal for pathway genes across RCC subtypes. Specific genes (blue) of a certain pathway and promiscuous genes (red) associating with multiple pathways are highlighted in order to compare the effect of promiscuity correction