Table 3 Prognostic pathways of various subtypes
Pathways | Log-rank test p-value | Benjamini-Hochberg FDR q-value | Expression status associated with poor survival | Dysregulation against normal tissues | Subtype |
|---|---|---|---|---|---|
PEROXISOME | 6.30E-11 | 1.57E-09 | Lower expression | Downregulated | ccRCC |
FATTY_ACID_METABOLISM | 3.17E-10 | 3.16E-09 | Lower expression | Downregulated | ccRCC |
ASCORBATE_AND_ALDARATE_METABOLISM | 3.82E-10 | 3.16E-09 | Lower expression | Downregulated | ccRCC |
TERPENOID_BACKBONE_BIOSYNTHESIS | 5.06E-10 | 3.16E-09 | Lower expression | Downregulated | ccRCC |
BETA_ALANINE_METABOLISM | 7.84E-09 | 3.92E-08 | Lower expression | Downregulated | ccRCC |
DRUG_METABOLISM_CYTOCHROME_P450 | 3.78E-08 | 1.57E-07 | Lower expression | Downregulated | ccRCC |
BUTANOATE_METABOLISM | 4.82E-08 | 1.72E-07 | Lower expression | Downregulated | ccRCC |
ARGININE_AND_PROLINE_METABOLISM | 7.71E-07 | 2.41E-06 | Lower expression | Downregulated | ccRCC |
TIGHT_JUNCTION | 6.81E-06 | 1.89E-05 | Lower expression | Downregulated | ccRCC |
SELENOAMINO_ACID_METABOLISM | 1.14E-05 | 2.85E-05 | Lower expression | Downregulated | ccRCC |
METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 | 3.13E-05 | 7.11E-05 | Lower expression | Downregulated | ccRCC |
TYROSINE_METABOLISM | 7.69E-05 | 0.000160213 | Lower expression | Downregulated | ccRCC |
PROSTATE_CANCER | 0.001937092 | 0.003725177 | Lower expression | Downregulated | ccRCC |
CARDIAC_MUSCLE_CONTRACTION | 0.003658082 | 0.006532289 | Lower expression | Downregulated | ccRCC |
EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION | 0.010330511 | 0.017217519 | Lower expression | Downregulated | ccRCC |
FOLATE_BIOSYNTHESIS | 0.021334521 | 0.033335189 | Lower expression | Downregulated | ccRCC |
GLUTATHIONE_METABOLISM | 0.035577554 | 0.052319932 | Lower expression | Downregulated | ccRCC |
SMALL_CELL_LUNG_CANCER | 0.014468144 | 0.102927174 | Higher expression | Downregulated | ChRCC |
AXON_GUIDANCE | 0.021736945 | 0.102927174 | Higher expression | Downregulated | ChRCC |
PROTEIN_EXPORT | 0.025731793 | 0.102927174 | Higher expression | Upregulated | ChRCC |
VASCULAR_SMOOTH_MUSCLE_CONTRACTION | 0.0302394 | 0.14745595 | Higher expression | Downregulated | PRCC |
ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHYARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY | 0.04406722 | 0.14745595 | Higher expression | Downregulated | PRCC |
SPLICEOSOME | 0.04564237 | 0.14745595 | Higher expression | Upregulated | PRCC |