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Table 3 Prognostic pathways of various subtypes

From: A pan-kidney cancer study identifies subtype specific perturbations on pathways with potential drivers in renal cell carcinoma

Pathways Log-rank test p-value Benjamini-Hochberg FDR q-value Expression status associated with poor survival Dysregulation against normal tissues Subtype
PEROXISOME 6.30E-11 1.57E-09 Lower expression Downregulated ccRCC
FATTY_ACID_METABOLISM 3.17E-10 3.16E-09 Lower expression Downregulated ccRCC
ASCORBATE_AND_ALDARATE_METABOLISM 3.82E-10 3.16E-09 Lower expression Downregulated ccRCC
TERPENOID_BACKBONE_BIOSYNTHESIS 5.06E-10 3.16E-09 Lower expression Downregulated ccRCC
BETA_ALANINE_METABOLISM 7.84E-09 3.92E-08 Lower expression Downregulated ccRCC
DRUG_METABOLISM_CYTOCHROME_P450 3.78E-08 1.57E-07 Lower expression Downregulated ccRCC
BUTANOATE_METABOLISM 4.82E-08 1.72E-07 Lower expression Downregulated ccRCC
ARGININE_AND_PROLINE_METABOLISM 7.71E-07 2.41E-06 Lower expression Downregulated ccRCC
TIGHT_JUNCTION 6.81E-06 1.89E-05 Lower expression Downregulated ccRCC
SELENOAMINO_ACID_METABOLISM 1.14E-05 2.85E-05 Lower expression Downregulated ccRCC
METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 3.13E-05 7.11E-05 Lower expression Downregulated ccRCC
TYROSINE_METABOLISM 7.69E-05 0.000160213 Lower expression Downregulated ccRCC
PROSTATE_CANCER 0.001937092 0.003725177 Lower expression Downregulated ccRCC
CARDIAC_MUSCLE_CONTRACTION 0.003658082 0.006532289 Lower expression Downregulated ccRCC
EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0.010330511 0.017217519 Lower expression Downregulated ccRCC
FOLATE_BIOSYNTHESIS 0.021334521 0.033335189 Lower expression Downregulated ccRCC
GLUTATHIONE_METABOLISM 0.035577554 0.052319932 Lower expression Downregulated ccRCC
SMALL_CELL_LUNG_CANCER 0.014468144 0.102927174 Higher expression Downregulated ChRCC
AXON_GUIDANCE 0.021736945 0.102927174 Higher expression Downregulated ChRCC
PROTEIN_EXPORT 0.025731793 0.102927174 Higher expression Upregulated ChRCC
VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0.0302394 0.14745595 Higher expression Downregulated PRCC
ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHYARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY 0.04406722 0.14745595 Higher expression Downregulated PRCC
SPLICEOSOME 0.04564237 0.14745595 Higher expression Upregulated PRCC