Fig. 5.

Representative subnetworks merged from the top 10 modules that were most significantly associated with each disorder. Subnetworks merged from the top 10 disorder-related significant modules. Nodes in purple indicated hub genes; nodes size is proportional to the corresponding GWAS gene p-value; edge width is proportional to the corresponding Pearson Correlation Coefficient of two genes. a ADHD_ST2_SC: attention deficit hyperactivity disorder stage 2 sub-cortical region; b ASD_ST2_SC: autism spectrum disorder stage 2 sub-cortical region; c BIP_ST2_FC: bipolar disorder stage 2 frontal cortex region; d MDD_ST3_FC: major depressive disorder stage 3 frontal cortex region; e SCZ_ST1_SC: schizophrenia stage 1 sub-cortical region. FC: frontal cortex region, SM: sensory motor region, SC: sub-cortical region, TP: temporal-parietal cortex region, ST1: stage 1 (prenatal), ST2: stage 2 (after birth to 11 years old), ST3: stage 3 (older than 13 years).