Copy number gain of pro-inflammatory genes in patients with HBV-related acute-on-chronic liver failure

BMC Medical Genomics

Table 1 Results of global rare CNV burden analysis

Type	Size (Kb)	RATE (case/control)	P value RATE^a	PROP (case/control)	P value PROP^b
Duplications and deletions	100–200	2.05/0.50	0.02	0.25/0.22	0.17
	200–500	0.68/0.14	0.05	0.07/0.10	0.93
	> 500	0.05/0.01	0.08	0.02/0.01	0.21
	All	2.78/0.66	0.03	0.29/0.28	0.42
Deletions	100–200	1.26/0.28	0.04	0.12/0.13	0.61
	200–500	0.49/0.07	0.06	0.05/0.06	0.73
	> 500	0.03/0	–	0.01/0	–
	All	1.78/0.35	0.04	0.15/0.16	0.68
Duplications	100–200	0.79/0.23	0.13	0.16/0.11	0.02
	200–500	0.19/0.07	0.24	0.03/0.05	0.94
	> 500	0.013/0.012	0.62	0.013/0.012	0.62
	All	0.99/0.31	0.14	0.18/0.16	0.16

^a,b is the numbers of rare CNV segments per person and the proportion of sample with one or more rare CNV segment, respectively

ISSN: 1755-8794