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Table 1 Baseline clinical characteristics of study subjects (n = 249)

From: Differential alternative splicing between hepatocellular carcinoma with normal and elevated serum alpha-fetoprotein

Variables (n = 249) AFP < 20 ng/mL
(n = 131, 52.6%)
AFP ≥ 20 ng/mL
(n = 118, 47.4%)
p value
Age (year)§ 60 ± 13 59 ± 13 0.300
Gender (male), n (%) 96 (73.3) 66 (55.9) 0.005
Race, n (%)    0.376
 White/Asian 72/59 (55.0/45.0) 58/60 (49.2/50.8)  
Cause of HCC, n (%)a (n = 129) (n = 117) 0.384+
 HBV 41 (31.8) 47 (40.2)  
 HCV 20 (15.5) 11 (9.4)  
 Alcohol 26 (20.1) 18 (15.4)  
 Mixed (HBV + HCV) 2 (1.6) 3 (2.6)  
 Others 40 (31.0) 38 (32.5)  
Liver cirrhosis, n (%)b (n = 96) (n = 70) 0.744
 Presence 36 (37.5) 24 (34.3)  
Vascular invasion, n (%)c (n = 121) (n = 110) 0.008+
 Absence/presence 89/32 (73.6/26.4) 62/48 (56.4/43.6)  
AJCC,7th, pTNM stage, n (%)d (n = 126) (n = 108) 0.468+
 I 76 (60.3) 57 (52.8)  
 II 30 (23.8) 26 (24.1)  
 III (A/B/C) 18 (14.3) 21 (19.4)  
 IV (A/B) 2 (1.6) 4 (3.7)  
  1. Liver cirrhosis was pathologically defined based on Ishak fibrosis score system
  2. AFP, Alpha-fetoprotein; HBV, hepatitis B virus; HCV, hepatitis C virus; LC, liver cirrhosis; AJCC, American Joint Committee on Cancer
  3. *P values were calculated using the t-test, the Chi-square test, or Fisher’s exact test, as appropriate
  4. Data for a, b, c, and d were available in 246, 166, 231, and 234 patients, respectively
  5. §Mean ± standard deviation
  6. +Fisher’s exact test