Table 2 Top MI-associated genes (68 protein-coding and 2 lincRNAs) at FDR < 0.1. Eight coding genes supported by p value and direction are in bold

APOD^a

3:195295572-195,311,076

301

− 0.19

1.29E-06

0.0075

0.63

Yes

0.51

DUS1L

17:80015381-80,023,763

902

0.41

1.97E-06

0.0075

0.778

No

0.331

AFF3

2:100162322-100,759,201

1478

−0.44

2.12E-06

0.0075

0.326

Yes

0.397

IRF7

11:612552-615,999

1652

0.41

2.50E-06

0.0075

0.286

Yes

0.378

IPO5

13:98605911-98,676,551

1866

−0.32

3.75E-06

0.0090

0.0416

Yes

0.115

SH3PXD2A

10:105348284-105,615,301

927

−0.40

5.93E-06

0.0119

0.248

Yes

0.0541

BACH2

6:90636247-91,006,627

3905

−0.37

1.09E-05

0.0188

0.48

Yes

0.586

PAX5

9:36833271-37,034,103

1406

−0.41

1.67E-05

0.0252

0.451

Yes

0.339

PHF6

X:133507282-133,562,820

704

−0.33

1.99E-05

0.0267

0.523

Yes

0.837

FCRL2

1:157715522-157,746,922

868

−0.40

2.26E-05

0.0272

0.482

Yes

0.37

VEZT

12:95611521-95,696,566

1024

−0.32

2.97E-05

0.0301

0.674

Yes

0.896

TRIM46

1:155145872-155,157,447

159

0.39

3.52E-05

0.0301

0.429

Yes

0.22

IFI6

1:27992571-27,998,729

1711

0.39

3.60E-05

0.0301

0.0291

Yes

0.0658

RAD52

12:1021242-1,099,219

1090

−0.30

3.75E-05

0.0301

0.65

No

0.394

BLK

8:11351509-11,422,113

562

−0.39

3.87E-05

0.0301

0.168

Yes

0.125

HLA-F

6:29690551-29,706,305

5562

0.27

3.99E-05

0.0301

0.307

Yes

0.286

IFI27

14:94571181-94,583,033

170

0.32

4.54E-05

0.0306

0.506

Yes

0.783

HNRNPR

1:23630263-23,670,829

2946

−0.26

4.56E-05

0.0306

0.00712

Yes

0.0141

ZNF44

19:12335500-12,405,702

671

−0.30

5.16E-05

0.0319

0.704

No

0.336

FCER2

19:7753643-7,767,032

592

−0.38

5.29E-05

0.0319

0.904

Yes

0.747

FRS2

12:69864128-69,973,562

1778

−0.26

5.88E-05

0.0328

0.913

No

0.576

HBG1

11:5269312-5,271,122

17,515

0.35

5.98E-05

0.0328

0.0753

Yes

0.38

PRKDC

8:48685668-48,872,743

9155

−0.22

6.59E-05

0.0337

0.41

Yes

0.907

MS4A1

11:60223224-60,238,233

3170

−0.38

6.91E-05

0.0337

0.217

Yes

0.163

FCRLA

1:161676761-161,684,142

562

−0.37

6.98E-05

0.0337

0.187

Yes

0.112

ACADVL

17:7120443-7,128,592

3648

0.26

8.06E-05

0.0370

0.061

No

0.0195

CCDC141

2:179694483-179,914,813

703

−0.37

8.28E-05

0.0370

0.398

Yes

0.884

HBG2

11:5274419-5,667,019

39,577

0.33

9.13E-05

0.0393

0.0082

Yes

0.0885

SKIL

3:170075465-170,114,623

1570

−0.25

9.53E-05

0.0396

0.42

No

0.493

GPT2

16:46918289-46,965,209

100

−0.32

0.00012109

0.0487

0.414

Yes

0.267

STRBP

9:125871778-126,030,855

1034

−0.34

0.00013802

0.0537

0.213

Yes

0.161

ZNF445

3:44481261-44,519,162

2182

−0.22

0.00014638

0.0552

0.995

Yes

0.681

RASGRF1

15:79252288-79,383,115

84

−0.22

0.00017229

0.0630

NA

NA

FIGNL1

7:50511830-50,518,088

234

−0.35

0.00017999

0.0639

0.61

No

0.394

PRKX

X:3522410-3,631,649

2556

−0.25

0.00018916

0.0652

0.0114

Yes

0.123

CLNK^a

4:10488018-10,686,489

96

−0.29

0.00020296

0.0670

NA

NA

DDX6

11:118620033-118,661,858

10,805

−0.18

0.0002167

0.0670

0.986

No

0.62

DESI2

1:244816236-244,872,335

945

−0.27

0.00021823

0.0670

0.24

Yes

0.564

NPDC1

9:139933921-139,940,655

146

0.34

0.00021874

0.0670

0.000883

Yes

0.00258

NXF1

11:62559594-62,573,774

7228

0.16

0.00022235

0.0670

0.864

Yes

0.973

RNF113A

X:119004496-119,005,791

297

0.34

0.00025995

0.0737

NA

NA

RARS

5:167913449-167,946,304

1359

−0.27

0.0002653

0.0737

0.496

Yes

0.401

RHOBTB2

8:22844929-22,877,712

558

−0.34

0.0002664

0.0737

0.0741

Yes

0.0351

UGGT1

2:128848773-128,953,251

4889

−0.18

0.00026872

0.0737

0.176

Yes

0.31

ISG15

1:948802-949,920

635

0.34

0.00028111

0.0752

0.382

Yes

0.635

TIPARP

3:156391023-156,424,559

938

−0.26

0.00028679

0.0752

0.434

Yes

0.789

KSR2

12:117890816-118,406,788

98

−0.15

0.00029511

0.0757

NA

NA

ATP6V0D1

16:67471916-67,515,140

8907

0.20

0.00032105

0.0807

0.792

Yes

0.966

FBXO11

2:48016454-48,132,932

1609

−0.23

0.00033474

0.0811

0.182

No

0.0272

ZNF274

19:58694395-58,724,928

840

−0.29

0.00033608

0.0811

0.668

No

0.196

MCOLN1

19:7587511-7,598,895

1777

0.32

0.00034818

0.0823

0.321

Yes

0.494

DDX24

14:94517265-94,547,591

2085

−0.27

0.0003551

0.0824

0.0259

Yes

0.138

PEX26

22:18560688-18,613,905

1308

−0.26

0.00036948

0.0835

0.0651

Yes

0.025

TBC1D23

3:99979843-100,044,095

1794

−0.22

0.00037386

0.0835

0.756

No

0.399

WNT3

17:44839871-44,910,520

137

−0.24

0.00039387

0.0858

NA

NA

RAB30

11:82684174-82,782,965

804

−0.31

0.00040083

0.0858

0.659

Yes

0.635

ODF3B

22:50968138-50,971,009

533

0.33

0.00040552

0.0858

0.36

Yes

0.265

CDK2AP2

11:67273967-67,276,120

771

0.32

0.00042475

0.0872

0.604

No

0.365

CDKN2D

19:10677137-10,679,735

4162

0.28

0.00043108

0.0872

0.0279

Yes

0.0662

SLC6A16

19:49792894-49,828,482

611

−0.32

0.00043371

0.0872

0.654

Yes

0.38

MOAP1

14:93648540-93,651,273

427

0.32

0.00044545

0.0881

0.0415

No

0.0489

IRF4

6:391738-411,447

1629

−0.30

0.00046627

0.0907

0.206

Yes

0.47

S100PBP

1:33282367-33,324,476

2679

−0.23

0.00048111

0.0913

0.918

No

0.843

GPR15

3:98250742-98,251,960

181

0.28

0.00048423

0.0913

0.162

Yes

0.0226

DNAH7

2:196602426-196,933,536

151

−0.33

0.00051455

0.0939

NA

NA

TCF20

22:42556018-42,739,622

4310

−0.21

0.00052057

0.0939

0.216

Yes

0.307

EIF2S3L

12:10658200-10,675,734

393

−0.27

0.00052155

0.0939

NA

NA

PSMB6

17:4699438-4,701,790

615

0.31

0.00056066

0.0995

0.406

No

0.245

LINC00452^b

13:114586639-114,588,308

14

−1.33

1.44E-05

0.0453

NA

NA

RP11-481 J2.2^b

16:58455229-58,496,374

10

−1.21

6.33E-05

0.0997

NA

NA