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Table 2 Distribution of IL-23A, IL-12B and IL-17A gene polymorphisms in healthy controls, pregnant woman and preeclampsia patients

From: IL-17A polymorphism (rs2275913) and levels are associated with preeclampsia pathogenesis in Chinese patients

Genotype/Allele

HW (nā€‰=ā€‰147)

PW (nā€‰=ā€‰102)

PE (nā€‰=ā€‰115)

PW vs PE (P value, OR, 95% CI)

IL-23A (rs11171806)

ā€ƒGG

135 (92)

95 (93)

92 (80)

1, ref

ā€ƒGA

11 (7)

7 (7)

22 (19)

0.008, 3.24, 1.31 to 8.53

ā€ƒAA

1 (1)

0

1 (1)

ā€“

ā€ƒG

281 (96)

197 (97)

206 (90)

1, ref

ā€ƒA

13 (4)

7 (3)

24 (10)

0.004, 3.27, 1.44 to 8.18

IL-12B (rs3212227)

ā€ƒAA

125 (85)

89 (87)

93 (81)

1, ref

ā€ƒAC

21 (14)

12 (12)

20 (17)

0.25, 1.59, 0.75 to 3.47

ā€ƒCC

1 (1)

1 (1)

2 (2)

1, 1.91, 0.21 to 28.01

ā€ƒA

271 (92)

190 (93)

206 (90)

1, ref

ā€ƒC

23 (8)

14 (7)

24 (10)

Ā 

IL-17A (rs2275913)

ā€ƒGG

54 (37)

39 (38)

24 (21)

1, ref

ā€ƒGA

62 (42)

44 (43)

65 (56)

0.007, 2.40, 1.29 to 4.47

ā€ƒAA

31 (21)

19 (19)

26 (23)

1, 0.96, 0.47 to 1.96

ā€ƒG

170 (58)

122 (60)

113 (49)

1, ref

ā€ƒA

124 (42)

82 (40)

117 (51)

0.02, 1.54, 1.05 to 2.25

IL-17A (rs1974226)

ā€ƒCC

129 (88)

87 (85)

102 (89)

1, ref

ā€ƒCT

16 (11)

13 (13)

13 (11)

0.83, 0.85, 0.37 to 1.94

ā€ƒTT

2 (1)

2 (2)

0

ā€“

ā€ƒC

274 (93)

187 (92)

217 (94)

1, ref

ā€ƒT

20 (7)

17 (8)

13 (6)

0.34, 0.65, 0.32 to 1.36

IL-17A (rs3748067)

ā€ƒCC

119 (81)

82 (80)

91 (79)

1, ref

ā€ƒCT

26 (18)

20 (20)

24 (21)

0.86, 1.08, 0.56 to 2.08

ā€ƒTT

2 (1)

0

0

ā€“

ā€ƒC

264 (90)

184 (90)

206 (90)

1, ref

ā€ƒT

30 (10)

20 (10)

24 (10)

0.87, 1.07, 0.58 to 2.04

  1. Data are presented in number (%)
  2. HW Healthy non-pregnant woman, PW Pregnant woman, PE Preeclampsia patients, OR Odds ratio, CI Confidence interval