|
Chr
|
Position
|
SNP
|
Closest gene
|
Distance
|
EA
|
NEA
|
EAF
|
Beta
|
SE
|
P-value
|
|---|
|
Genome-wide significant association
|
|
4
|
165473425
|
rs4691991
|
MARCH1
|
169 kb
|
C
|
G
|
0.29
|
− 0.210
|
0.037
|
1.90 × 10–8
|
|
Suggestive associations
|
|
7
|
151616838
|
rs7794104
|
PRKAG2/GALNTL5
|
42 kb/36 kb
|
T
|
C
|
0.92
|
− 0.334
|
0.067
|
6.89 × 10–7
|
|
9
|
98523829
|
rs7864076
|
ERCC6L2
|
114 kb
|
T
|
C
|
0.49
|
− 0.162
|
0.033
|
9.75 × 10–7
|
|
18
|
62985882
|
rs17689596
|
CDH7
|
431 kb
|
T
|
G
|
0.067
|
− 0.316
|
0.065
|
1.11 × 10–6
|
|
1
|
181531664
|
rs80231151
|
CACNA1E
|
Intergenic
|
G
|
A
|
0.082
|
− 0.305
|
0.065
|
2.38 × 10–6
|
|
5
|
161945575
|
rs56820633
|
GABRG2
|
363 kb
|
A
|
T
|
0.096
|
0.270
|
0.058
|
2.80 × 10–6
|
|
13
|
97508453
|
rs16953620
|
HS6ST3
|
16 kb
|
A
|
G
|
0.86
|
− 0.218
|
0.047
|
3.23 × 10–6
|
|
15
|
39161381
|
rs12442819
|
RASGRP1
|
304 kb
|
T
|
G
|
0.29
|
− 0.171
|
0.038
|
7.68 × 10–6
|
|
6
|
99283376
|
rs195860
|
POU3F2
|
Intergenic
|
T
|
G
|
0.13
|
− 0.215
|
0.048
|
8.72 × 10–6
|
|
14
|
65833499
|
rs10149004
|
FUT8
|
43 kb
|
C
|
T
|
0.13
|
− 0.211
|
0.048
|
9.11 × 10–6
|
- Beta (SE) from linear mixed model denotes the effect of each of the effect alleles (EA, additive model) on the inverse-normalized residuals of trait adjusted for age, sex and BMI. Effect denotes the change in percent in plasma glucagon concentration for each of the EAs obtained from a linear mixed model on the logarithmically transformed plasma levels adjusted for age, sex and BMI. Chr chromosome, NEA non effect allele, EAF effect allele frequency. Distance indicates how far from the gene the marker is located
