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Table 2 Genome-wide significant and suggestive loci for dAUC 0–30 min of plasma glucagon levels during an OGTT

From: Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

Chr Position SNP Closest gene Distance EA NEA EAF Beta SE P-value
Genome-wide significant association
4 165473425 rs4691991 MARCH1 169 kb C G 0.29 − 0.210 0.037 1.90 × 10–8
Suggestive associations
7 151616838 rs7794104 PRKAG2/GALNTL5 42 kb/36 kb T C 0.92 − 0.334 0.067 6.89 × 10–7
9 98523829 rs7864076 ERCC6L2 114 kb T C 0.49 − 0.162 0.033 9.75 × 10–7
18 62985882 rs17689596 CDH7 431 kb T G 0.067 − 0.316 0.065 1.11 × 10–6
1 181531664 rs80231151 CACNA1E Intergenic G A 0.082 − 0.305 0.065 2.38 × 10–6
5 161945575 rs56820633 GABRG2 363 kb A T 0.096 0.270 0.058 2.80 × 10–6
13 97508453 rs16953620 HS6ST3 16 kb A G 0.86 − 0.218 0.047 3.23 × 10–6
15 39161381 rs12442819 RASGRP1 304 kb T G 0.29 − 0.171 0.038 7.68 × 10–6
6 99283376 rs195860 POU3F2 Intergenic T G 0.13 − 0.215 0.048 8.72 × 10–6
14 65833499 rs10149004 FUT8 43 kb C T 0.13 − 0.211 0.048 9.11 × 10–6
  1. Beta (SE) from linear mixed model denotes the effect of each of the effect alleles (EA, additive model) on the inverse-normalized residuals of trait adjusted for age, sex and BMI. Effect denotes the change in percent in plasma glucagon concentration for each of the EAs obtained from a linear mixed model on the logarithmically transformed plasma levels adjusted for age, sex and BMI. Chr chromosome, NEA non effect allele, EAF effect allele frequency. Distance indicates how far from the gene the marker is located