Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

BMC Medical Genomics

Table 2 Genome-wide significant and suggestive loci for dAUC 0–30 min of plasma glucagon levels during an OGTT

Chr	Position	SNP	Closest gene	Distance	EA	NEA	EAF	Beta	SE	P-value
Genome-wide significant association
4	165473425	rs4691991	MARCH1	169 kb	C	G	0.29	− 0.210	0.037	1.90 × 10^–8
Suggestive associations
7	151616838	rs7794104	PRKAG2/GALNTL5	42 kb/36 kb	T	C	0.92	− 0.334	0.067	6.89 × 10^–7
9	98523829	rs7864076	ERCC6L2	114 kb	T	C	0.49	− 0.162	0.033	9.75 × 10^–7
18	62985882	rs17689596	CDH7	431 kb	T	G	0.067	− 0.316	0.065	1.11 × 10^–6
1	181531664	rs80231151	CACNA1E	Intergenic	G	A	0.082	− 0.305	0.065	2.38 × 10^–6
5	161945575	rs56820633	GABRG2	363 kb	A	T	0.096	0.270	0.058	2.80 × 10^–6
13	97508453	rs16953620	HS6ST3	16 kb	A	G	0.86	− 0.218	0.047	3.23 × 10^–6
15	39161381	rs12442819	RASGRP1	304 kb	T	G	0.29	− 0.171	0.038	7.68 × 10^–6
6	99283376	rs195860	POU3F2	Intergenic	T	G	0.13	− 0.215	0.048	8.72 × 10^–6
14	65833499	rs10149004	FUT8	43 kb	C	T	0.13	− 0.211	0.048	9.11 × 10^–6

Beta (SE) from linear mixed model denotes the effect of each of the effect alleles (EA, additive model) on the inverse-normalized residuals of trait adjusted for age, sex and BMI. Effect denotes the change in percent in plasma glucagon concentration for each of the EAs obtained from a linear mixed model on the logarithmically transformed plasma levels adjusted for age, sex and BMI. Chr chromosome, NEA non effect allele, EAF effect allele frequency. Distance indicates how far from the gene the marker is located

ISSN: 1755-8794