Role of ATF3 as a prognostic biomarker and correlation of ATF3 expression with macrophage infiltration in hepatocellular carcinoma

Table 3 Kinase, miRNA, and transcription factor targets of ATF3 in HCC

Category	Gene set	LeadingEdgeNum	FDR
Kinase	Kinase_MAPK8	76	0
	Kinase_IKBKB	9	0.040725
	Kinase_CDK3	7	0.084733
	Kinase_GSK3B	14	0.085654
	Kinase_FER	8	0.079594
miRNA	ATTACAT, MIR-380-3P	24	0
	TGAATGT, MIR-181A, MIR-181B, MIR-181C, MIR-181D	93	0.0028376
	TATTATA, MIR-374	54	0.0028376
	ACTTTAT, MIR-142-5P	62	0.0033105
	TAATGTG, MIR-323	43	0.0035470
Transcription Factor	V$ATF3_Q6	38	0
	V$CREBP1_Q2	53	0
	V$ATF_01	34	0
	V$CREB_Q2_01	31	0
	V$CREB_Q2	34	0

LeadingEdgeNum, number of leading edge genes; FDR, false discovery rate from Benjamini and Hochberg tests from a gene set enrichment analysis (GSEA). V$, annotation in the Molecular Signatures Database (MSigDB) for transcription factors (TF)

ISSN: 1755-8794