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Table 6 Effect of covariates in linear model used to adjust median TG

From: Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort

Variable

β

p

Age

−4.04e−05

2.15e−07

Sex (Male)

0.02

3.08e−09

BMI

0.01

2.46e−132

APOE (rs429358)

0.01

1.98e−03

APOE (rs7412)

0.04

1.65e−11

GCKR (rs1260326)

0.03

1.23e−27

APOA1/C3/A4/A5 gene cluster (rs964184)

0.04

1.58e−29

APOC3

−0.23

1.32e−21

APOA5 (rs2075291)

0.09

2.65e−05

PC1

−2.84

2.57e−09

PC2

−2.17

8.62e−11

SITE

NA

 < 2e−16

HTG

0.3

3.34e−176

HL

0.08

6.92e−72

  1. Age = centered-median-age-squared, BMI = median BMI, SITE = indicators for each site, HTG = hypertriglyceridemia, HL = unspecified or mixed hyperlipidemia and other unspecified disorders of lipid metabolism. Participant counts for HL exclude participants with HTG. PC = Principal component of ancestry. APOC3 is an indicator for genotype at 4 SNVs (rs76353203, rs147210663, rs138326449, rs140621530)