Genetic association between CDKN2B/CDKN2B-AS1 gene polymorphisms with primary glaucoma in a North Indian cohort: an original study and an updated meta-analysis

Table 2 Allele/genotype frequency distributions and genetic model analysis for CDKN2B rs3217992and rs1063192among POAG, PACG and controls

Genotype/Allele	POAG n = 313 (%)	Control n = 444 (%)	Chisq value	p value	OR(95% CI)
rs3217992
T	249 (39.77)	399 (44.93)	3.987	0.045*	0.80 (0.65–0.99)
C	377 (60.23)	489 (55.07)	Ref	Ref
TT	55 (17.57)	93 (20.95)	4.173	0.074	0.68 (0.45–1.03)
CT	139 (44.41)	213 (47.97)		0.093	0.75 (0.54–1.04)
CC	119 (38.02)	138 (31.08)		Ref
Dominant model	194/119	306/138	3.941	0.047*	0.73 (0.54–0.99)
Recessive model	55/258	93/351	1.329	0.249	0.80 (0.55–1.16)
Codominant model	139/174	213/231	0.800	0.333	0.86 (0.64–1.15)
CA trend under additive model	249/377	399/489	3.796	0.046*	0.80 (0.65–0.99)

rs1063192	POAG n = 313 (%)	Control n = 449 (%)	Chisq value	p value	OR(95% CI)
G	178 (28.43)	248 (27.62)	0.122	0.726	1.04 (0.82–1.30)
A	448 (71.57)	650 (72.38)	Ref	Ref
GG	21 (6.71)	34 (7.57)	0.917	0.807	0.93 (0.52–1.66)
GA	136 (43.45)	180 (40.09)		0.399	1.13 (0.84–1.53)
AA	156 (49.84)	235 (52.34)		Ref
Dominant model	157/156	214/235	0.460	0.497	1.10 (0.82–1.47)
Recessive model	21/992	34/415	0.205	0.650	0.87 (0.49–1.54)
Co-dominant model	136/177	180/269	0.726	0.354	1.14 (0.85–1.53)
CA trend assuming additive model	178/448	248/650	0.126	0.726	1.04 (0.82–1.30)

rs3217992	PACG n = 147(%)	Control n = 444(%)	Chisq value	p value	OR (95% CI)
T	110 (37.41)	399 (44.93)	5.091	0.024*	0.73 (0.55–0.96)
C	184 (62.59)	489 (55.07)	Ref	Ref
TT	21 (14.29)	93 (20.95)	4.943	0.030*	0.53 (0.30–0.94)
CT	68 (46.26)	213 (47.97)		0.189	0.75 (0.50–1.14)
CC	58 (39.45)	138 (31.08)		Ref
Dominant model	89/58	306/138	3.494	0.061	0.69 (0.46–1.01)
Recessive model	21/126	93/315	3.147	0.076	0.62 (0.37–1.05)
Codominant model	68/79	213/231	0.070	0.718	0.93 (0.64–1.35)
CA trend assuming additive model	110/184	399/489	4.941	0.030*	0.53 (0.30–0.94)

rs1063192	PACG n = 148(%)	Control n = 449(%)	Chisq value	p value	OR (95% CI)
G	70 (23.65)	248 (27.62)	1.794	0.180	0.81 (0.59–1.10)
A	226 (76.35)	650 (72.38)	Ref	Ref
GG	9 (6.08)	34 (7.57)	1.904	0.396	0.71 (0.32–1.55)
GA	52 (35.14)	180 (40.09)		0.218	0.78 (0.52–1.15)
AA	87 (58.78)	235 (52.34)		Ref
Dominant model	61/87	214/235	1.861	0.172	0.77 (0.52–1.12)
Recessive model	9/139	34/415	0.370	0.542	0.79 (0.36–1.68)
Codominant model	52/96	180/269	0.951	0.228	0.80 (0.54–1.19)
CA trend assuming additive model	70/226	248/650	1.784	0.181	0.81 (0.59–1.10)

CA Cochran Armitage trend test
*p value < 0.05 was considered to be statistically significant and are in bold; Bonferroni corrected p value: 0.003 Ref indicates allele/genotype considered as reference while calculating odds ratio and p values (in bold)

ISSN: 1755-8794