Table 4 Allele/Genotype frequency distributions and genetic model analysis for CDKN2B-AS1 rs2157719 and rs4977756 among POAG, PACG and controls
Genotype/Allele | POAG n = 312 (%) | Control n = 442 (%) | Chisq value | p value | OR(95% CI) |
|---|---|---|---|---|---|
rs2157719 | |||||
C | 173 (27.72) | 292 (33.03) | 4.831 | 0.0279* | 0.77(0.62–0.97) |
T | 451 (72.28) | 592 (66.96) | Ref | Ref | Â |
CC | 19 (6.09) | 65 (14.70) | 14.37 | 0.0010* | 0.39 (0.22–0.69) |
CT | 135 (43.27) | 162 (36.65) | 0.4224 | 1.13(0.83–1.54) | |
TT | 158 (50.64) | 215 (48.64) | Ref | Â | |
Dominant model | 154/158 | 227/215 | 0.292 | 0.5888 | 0.92(0.69–1.23) |
Recessive model | 19/293 | 65/377 | 13.72 | 0.0002* | 0.37(0.22–0.64) |
Codominant model | 135/177 | 162/280 | 3.083 | 0.0673 | 1.31(0.98–1.77) |
CA trend assuming additive model | 173/451 | 292/592 | 4.488 | 0.0281* | 0.77(0.62–0.97) |
rs4977756 | POAG n = 313 (%) | Control n = 444 (%) | Chisq value | p value | OR(95% CI) |
|---|---|---|---|---|---|
G | 165 (26.36) | 232 (26.13) | 0.010 | 0.919 | 1.01(0.80–1.27) |
A | 461 (73.64) | 656 (73.87) | Ref | Ref | Â |
GG | 18 (5.75) | 33 (7.43) | 1.616 |  | 0.80(0.43–1.47) |
GA | 129 (41.21) | 166 (37.39) |  | 1.14(0.84–1.55) | |
AA | 166 (53.04) | 245 (55.18) | Ref | Â | |
Dominant model | 147/166 | 199/245 | 0.340 | 0.559 | 1.09(0.81–1.45) |
Recessive model | 18/295 | 33/411 | 0.826 | 0.363 | 0.75(0.41–1.37) |
Codominant model | 129/184 | 166/278 | 0.975 | 0.287 | 1.17(0.87–1.57) |
Additive model | 165/461 | 232/656 | 0.010 | 0.919 | 1.01(0.80–1.27) |
rs2157719 | PACG n = 147(%) | Control n = 442(%) | Chisq value | p value | OR (95% CI) |
|---|---|---|---|---|---|
C | 71 (24.15) | 292 (33.03) | 8.164 | 0.004* | 0.64 (0.47–0.87) |
T | 223 (75.85) | 592 (66.96) | Ref | Ref | Â |
CC | 9 (6.13) | 65 (14.70) | 8.305 | 0.005* | 0.35 (0.16–0.73) |
CT | 53 (36.05) | 162 (36.65) | 0.352 | 0.82 (0.55–1.23) | |
TT | 85 (57.82) | 215 (48.64) | Ref | Â | |
Dominant model | 62/85 | 227/215 | 3.72 | 0.053* | 0.69 (0.47–1.00) |
Recessive model | 9/138 | 65/377 | 7.398 | 0.006* | 0.37 (1.83–0.78) |
Codominant model | 53/94 | 162/280 | 0.010 | 0.896 | 0.97 (0.66–1.43) |
CA trend assuming additive model | 71/223 | 292/592 | 7.137 | 0.004* | 0.64 (0.47–0.87) |
rs4977756 | PACG n = 147(%) | Control n = 444(%) | Chisq value | p value | OR (95% CI) |
|---|---|---|---|---|---|
G | 65 (22.11) | 232 (26.13) | 1.895 | 0.168 | 0.80 (0.58–1.09) |
A | 229 (77.89) | 656 (73.87) | Ref | Ref | Â |
GG | 7 (4.76) | 33 (7.43) | 1.944 | 0.215 | 0.58 (0.24–1.36) |
GA | 51 (34.69) | 166 (37.38) | 0.407 | 0.84 (0.56–1.25) | |
AA | 89 (60.54) | 245 (55.18) | Ref | Â | |
Dominant model | 58/89 | 199/245 | 1.293 | 0.255 | 0.80 (0.54–1.17) |
Recessive model | 7/140 | 33/411 | 1.248 | 0.263 | 0.62 (0.26–1.43) |
Codominant model | 51/96 | 166/278 | 0.239 | 0.557 | 0.88 (0.60–1.31) |
CA trend assuming additive model | 65/229 | 232/656 | 1.85 | 0.169 | 0.80 (0.58–1.09) |