Table 3 Enrichment results of the candidate gene markers
Term | Count | P value | Genes |
|---|---|---|---|
Biology process | |||
GO:0006929 ~ substrate-bound cell migration | 4 | 6.96E−04 | VEGFC, TNFRSF12A, ATP5B, MYH10 |
GO:0032101 ~ regulation of response to external stimulus | 10 | 0.001453 | EDNRA, GPX1, ADRB2, CYP27B1, ADORA2B, OSMR, FCER1G, GREM1, ADA, PLAU |
GO:0051186 ~ cofactor metabolic process | 11 | 0.001691 | MTHFS, GPX1, ALAS1, HMBS, SUCLG1, MCCC1, ALDOB, GIF, UROD, PDHB, MDH1 |
GO:0050727 ~ regulation of inflammatory response | 7 | 0.001717 | EDNRA, GPX1, ADRB2, ADORA2B, OSMR, FCER1G, ADA |
GO:0008202 ~ steroid metabolic process | 11 | 0.002193 | TM7SF2, OSBPL2, CYP27B1, SULT1B1, INSIG1, SCARB1, NR3C1, CAT, NR0B2, HSD17B8, FDFT1 |
GO:0016052 ~ carbohydrate catabolic process | 8 | 0.002391 | HYAL2, ALDOB, CHI3L1, FUT1, CTBS, PDHB, MDH1, ENO1 |
GO:0006091 ~ generation of precursor metabolites and energy | 14 | 0.002446 | NDUFB5, NDUFA9, KL, ATP5B, SUCLG1, FADS1, ALDOB, CRAT, PDHB, GFPT2, CAT, ENO1, ATP5J, MDH1 |
GO:0006000 ~ fructose metabolic process | 4 | 0.002665 | ALDOB, GFPT2, FBP1, FBP2 |
GO:0015980 ~ energy derivation by oxidation of organic compounds | 9 | 0.002965 | NDUFB5, KL, NDUFA9, SUCLG1, GFPT2, CRAT, CAT, PDHB, MDH1 |
GO:0006090 ~ pyruvate metabolic process | 5 | 0.005245 | ALDOB, FBP1, FBP2, PDHX, PDHB |
GO:0030334 ~ regulation of cell migration | 9 | 0.007713 | PTPRK, VEGFC, MMP9, PTP4A1, RRAS2, SCARB1, GREM1, SST, ADA |
GO:0006766 ~ vitamin metabolic process | 6 | 0.008483 | DHRS3, CYP27B1, ACADM, MCCC1, TMLHE, GIF |
GO:0044271 ~ nitrogen compound biosynthetic process | 13 | 0.008797 | ATP5B, HMBS, ATP11B, PFAS, ADA, ADI1, ALAS1, TMLHE, NQO1, UROD, IMPDH1, ATP5J, ATP8A1 |
GO:0009310 ~ amine catabolic process | 6 | 0.009967 | MAOA, AMT, MCCC1, DDAH1, AUH, ENOSF1 |
KEGG pathway | |||
hsa00280:Valine, leucine and isoleucine degradation | 6 | 0.003379 | ACADM, IVD, OXCT1, MCCC1, PCCB, AUH |
hsa05219:Bladder cancer | 5 | 0.016087 | RPS6KA5, VEGFC, CDKN1A, MMP9, CDK4 |
hsa03410:Base excision repair | 4 | 0.047523 | POLL, POLD1, NEIL1, PARP1 |
hsa00010:Glycolysis/Gluconeogenesis | 5 | 0.045098 | ALDOB, FBP1, FBP2, PDHB, ENO1 |
hsa00100:Steroid biosynthesis | 3 | 0.045875 | TM7SF2, CYP27B1, FDFT1 |