Table 3 Multiple linear regression showing the association between dietary fat and cg02263260 methylation in Taiwanese adults stratified by sex

Dietary fat

 Low (reference)

–

–

–

–

–

–

–

–

 Moderate

0.00285

− 0.00130

0.00700

0.1774

− 0.00213

− 0.00734

0.00307

0.4207

 High

0.00597

0.00061

0.01133

0.0292

− 0.00419

− 0.01011

0.00172

0.1642

P-trend 0.0283

P-trend 0.1600

Age

− 0.00002

− 0.00022

0.00019

0.8763

0.00002

− 0.00017

0.00022

0.8053

BMI

− 0.00014

− 0.00087

0.00058

0.6969

− 0.00004

− 0.00083

0.00075

0.9285

Body fat

 Men < 25; women < 30 (reference)

–

–

–

–

–

–

–

–

 Men ≥ 25; women ≥ 30

0.00247

− 0.00246

0.00739

0.3256

0.00204

− 0.00316

0.00724

0.4413

Waist-hip ratio

 Men ≤ 0.9; women ≤ 0.85 (reference)

–

–

–

–

–

–

–

–

 Men > 0.9; women > 0.85

− 0.00139

− 0.00549

0.00270

0.5041

− 0.00173

− 0.00616

0.00271

0.4451

Exercise

 No (reference)

–

–

–

–

–

–

–

–

 Yes

0.00332

− 0.00053

0.00716

0.0908

− 0.00095

− 0.00502

0.00311

0.6446

Cigarette smoking

 Never (reference)

–

–

–

–

–

–

–

–

 Former

− 0.00148

− 0.01081

0.00784

0.7545

0.00054

− 0.00411

0.00520

0.8192

 Current

− 0.00751

− 0.01841

0.00338

0.1759

− 0.00096

− 0.00615

0.00424

0.7171

Alcohol drinking

 Never (reference)

–

–

–

–

–

–

–

–

 Former

0.00349

− 0.01757

0.02455

0.7446

− 0.00019

− 0.00911

0.00873

0.9667

 Current

0.00571

− 0.01071

0.02213

0.4947

0.00043

− 0.00537

0.00623

0.8842

Coffee consumption

 No (reference)

–

–

–

–

–

–

–

–

 Yes

− 0.00125

− 0.00496

0.00247

0.5094

0.00055

− 0.00339

0.00450

0.7828

Tea consumption

 No (reference)

–

–

–

–

–

–

–

–

 Yes

0.00350

− 0.00032

0.00731

0.0721

− 0.00092

− 0.00476

0.00293

0.6393

Vegetarian diet

 No (reference)

–

–

–

–

–

–

–

–

 Yes

0.00242

− 0.00531

0.01015

0.5393

− 0.00250

− 0.01412

0.00913

0.6732

HDL-C

− 0.00017

− 0.00041

0.00007

0.1718

0.00003

− 0.00025

0.00032

0.8121

LDL-C

− 0.00003

− 0.00022

0.00017

0.7916

− 0.00002

− 0.00024

0.00020

0.8830

TG

− 0.00001

− 0.00005

0.00002

0.3538

0.00000

− 0.00005

0.00004

0.8367

TC

0.00000

− 0.00019

0.00019

0.9953

0.00005

− 0.00017

0.00027

0.6497