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Fig. 2 | BMC Medical Genomics

Fig. 2

From: A splice-site variant (c.3289-1G>T) in OTOF underlies profound hearing loss in a Pakistani kindred

Fig. 2

Pure-tone audiometry and tympanometry. a Pure-tone audiograms of a normal subject (IV-16) and an affected subject (IV-2). The vertical axis indicates the sound level in decibels (dB), and the horizontal axis shows frequency in hertz (Hz). Audiograms of both ears are presented. ‘x’ represents air conduction, and <> indicates bone conduction. b Tympanometry or tympanogram. (i) Normal subject (IV-16); his right-ear peak was 0.4 lower than the left-ear peak of 0.7 cm3 but remained within the normal range (type ‘A’). (ii) Affected subject (IV-9); his right ear peak was 0.1 cm3 (type ‘As’), but his left ear peak was 0.4 cm3 and belonged to type ‘A’. The vertical axis shows compliance or flexibility in cm3 (1.5 cm3). The horizontal axis shows air pressure in decaPascals (daPa), ECV = ear canal volume, GR = gradient. R = right, L = left,

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