Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia

Table 3 Candidate variants showing a significant association with type 2 diabetes complications

CHR	Closest gene	SNP	A1/A2	MAF cases/controls	MAF European	OR (95% CI)	P-value	FDR	References
Neuropathies
6:35993906	MAPK14, SLC26A8	rs3761980	G/A	0.13/0.09	0.10	1.58 (1.08–2.33)	1.94E-02	3.88E-02	Meng et al. [49]
6:35998388	MAPK14	rs80028505	T/C	0.13/0.09	0.11	1.58 (1.08–2.33)	1.94E-02	3.88E-02	Meng et al. [49]
Nephropathies
22:36657432	APOL1	rs136161	G/C	0.47/ 0.29	0.40	2.00 (1.40–2.86)	1.41E-04	6.93E-03	Iyengar et al. [50]

CHR chromosome and base pair position in Human Genome build hg19, A1 minor allele, A2 major allele, OR odds ratio for the minor allele, CI confidence interval 95%, FDR false discovery rate by Benjamini & Hochberg method, MAF minor allele frequency, MAF European: minor allele frequency observed in the European population [31]

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